학술논문
Herbicide exposure modifies GSTP1haplotype association to Parkinson onset age
Document Type
Article
Author
Wilk, J B.; Tobin, J E.; Suchowersky, O; Shill, H A.; Klein, C; Wooten, G F.; Lew, M F.; Mark, M H.; Guttman, M; Watts, R L.; Singer, C; Growdon, J H.; Latourelle, J C.; Saint-Hilaire, M H.; DeStefano, A L.; Prakash, R; Williamson, S; Berg, C J.; Sun, M; Goldwurm, S; Pezzoli, G; Racette, B A.; Perlmutter, J S.; Parsian, A; Baker, K B.; Giroux, M L.; Litvan, I; Pramstaller, P P.; Nicholson, G; Burn, D J.; Chinnery, P F.; Vieregge, P; Slevin, J T.; Cambi, F; MacDonald, M E.; Gusella, J F.; Myers, R H.; Golbe, L I.
Source
Neurology (Ovid); December 2006, Vol. 67 Issue: 12 p2206-2210, 5p
Subject
Language
ISSN
00283878; 1526632X
Abstract
Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. Using the GenePD Study sample of familial PD cases, we explored whether GSTP1polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides.