학술논문
The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer
Document Type
Article
Author
Source
Current Pharmaceutical Design; November 2018, Vol. 24 Issue: 39 p4639-4645, 7p
Subject
Language
ISSN
13816128
Abstract
Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.