학술논문
Alzheimer Patients Treated With an AchE Inhibitor Show Higher IL-4 and Lower IL-1β Levels and Expression in Peripheral Blood Mononuclear Cells
Document Type
Article
Author
Source
Journal of Clinical Psychopharmacology; June 2004, Vol. 24 Issue: 3 p314-321, 8p
Subject
Language
ISSN
02710749; 1533712X
Abstract
The study evaluates the expression and production of cytokines in peripheral blood mononuclear cells of patients with Alzheimer disease treated or not treated with acetylcholinesterase inhibitor, which enhances neuronal transmission. Cytokines associated with brain inflammation such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α have been implicated in the regulation of amyloid peptide protein synthesis. The anti-inflammatory cytokine, IL-4, may suppress the activity of IL-1β.