학술논문
Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vsemtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial
Document Type
Article
Author
Ogbuagu, Onyema; Ruane, Peter J; Podzamczer, Daniel; Salazar, Laura C; Henry, Keith; Asmuth, David M; Wohl, David; Gilson, Richard; Shao, Yongwu; Ebrahimi, Ramin; Cox, Stephanie; Kintu, Alexander; Carter, Christoph; Das, Moupali; Baeten, Jared M; Brainard, Diana M; Whitlock, Gary; Brunetta, Jason M; Kronborg, Gitte; Spinner, Christoph D; Antinori, Andrea; Apea, Vanessa; Asmuth, David; Avery, Ann; Benson, Paul; Bergin, Colm; Berhe, Mezgebe; Brar, Indira; Brinson, Cynthia; Brunetta, Jason; Burack, Jeffrey; Campbell, Thomas; Cespedes, Michelle; Clarke, Amanda; Coleman, Megan; Coll, Josep; Crespo Casal, Manuel; Creticos, Catherine; Crofoot, Gordon; Cruickshank, Frederick; Cua, Eric; Daar, Eric; de Wet, Joseph; DeJesus, Edwin; Del Romero Guerrero, Jorge; Dinges, William; Doblecki-Lewis, Susanne; Donovan, Taylor; Dosekun, Olamide; Flamm, Jason; Gallant, Joel; Gerstoft, Jan; Gilson, Richard; Gladstein, Jay; Grant, Robert; Grossberg, Robert; Haas, Bernhard; Halperin, Jason; Hardy, W. David; Hare, Charles; Hassler, Shawn; Hengel, Richard; Henry, William; Hodge, Theo; Hosek, Sybil; Hurt, Christopher; Iandiorio, Michelle; Jessen, Heiko; Kegg, Stephen; Knecht, Gabriele; Kronborg, Gitte; Krznaric, Ivanka; LaMarca, Anthony; Larsen, Carsten Schade; Larsen, Olav Ditlevsen; Lazzarin, Adriano; Leen, Clifford; Lucasti, Christopher; Mallon, Patrick; Mannheimer, Sharon; Markowitz, Martin; Martorell, Claudia; Mayer, Kenneth; Mills, Anthony; Molina, Jean-Michel; Morris, Sheldon; Mounzer, Karam; Nwokolo, Nneka; Ogbuagu, Onyema; Osiyemi, Olayemi; Petroll, Andrew; Philibert, Patrick; Phoenix, John; Pialoux, Gilles; Podzamczer, Daniel; Post, Frank; Prins, Maria; Ramgopal, Moti; Rashbaum, Bruce; Reeves, Iain; Richmond, Gary; Rieger, Armin; Ruane, Peter; Salazar, Laura; Scarsella, Anthony; Schembri, Gabriel; Scott, Mia; Shalit, Peter; Sinclair, Gary; Sobieszczyk, Magdalena; Spinner, Christoph; Stephens, Jeffrey; Szabo, Jason; Taylor, Stephen; Thompson, Melanie; Tremblay, Cecile; Trottier, Benoit; Voskuhl, Gene; Wade, Barbara; Wohl, David; Workowski, Kimberly; Yawetz, Sigal; Young, Benjamin
Source
The Lancet HIV; July 2021, Vol. 8 Issue: 7 pe397-e407, 11p
Subject
Language
ISSN
24054704; 23523018
Abstract
In DISCOVER, a multinational, randomised controlled trial, emtricitabine and tenofovir alafenamide compared with emtricitabine and tenofovir disoproxil fumarate showed non-inferior efficacy for HIV prevention and improved bone mineral density and renal safety biomarkers at week 48. We report outcomes analysed after all participants had completed 96 weeks of follow-up.