학술논문
Mechanistic Insights into the Racemization of Fused Cyclopropyl Isoxazolines
Document Type
Article
Author
Source
Organic Letters; March 2020, Vol. 22 Issue: 6 p2113-2117, 5p
Subject
Language
ISSN
15237060; 15237052
Abstract
Experimental and computational studies of the unexpected racemization of enantiopure fused cyclopropyl isoxazolines are reported. These studies offer insights into the mechanism of racemization, quantify the position of the transition state on the dipolar–diradical continuum, and establish a relationship between the structure and stability of this class of compounds. Experimental and computed energy barriers for racemization are also presented.