학술논문
β-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism
Document Type
Article
Source
Molecular Biology of the Cell; June 2020, Vol. 31 Issue: 13 p1425-1436, 12p
Subject
Language
ISSN
10591524; 19394586
Abstract
A novel tool for quantitative, real-time assessment of Wnt pathway activation was combined with genetic disruption of endocytosis to determine whether receptor endocytosis is required for Wnt signal transduction. Our results in multiple cell lines support that clathrin- or caveolin-mediated endocytosis is dispensable for Wnt signal transduction.