학술논문
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Document Type
Article
Author
Lee, James J.; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N.; Walters, Raymond K.; Willoughby, Emily A.; Yengo, Loïc; Alver, Maris; Bao, Yanchun; Clark, David W.; Day, Felix R.; Furlotte, Nicholas A.; Joshi, Peter K.; Kemper, Kathryn E.; Kleinman, Aaron; Langenberg, Claudia; Mägi, Reedik; Trampush, Joey W.; Verma, Shefali Setia; Wu, Yang; Lam, Max; Zhao, Jing Hua; Zheng, Zhili; Boardman, Jason D.; Campbell, Harry; Freese, Jeremy; Harris, Kathleen Mullan; Hayward, Caroline; Herd, Pamela; Kumari, Meena; Lencz, Todd; Luan, Jian’an; Malhotra, Anil K.; Metspalu, Andres; Milani, Lili; Ong, Ken K.; Perry, John R. B.; Porteous, David J.; Ritchie, Marylyn D.; Smart, Melissa C.; Smith, Blair H.; Tung, Joyce Y.; Wareham, Nicholas J.; Wilson, James F.; Beauchamp, Jonathan P.; Conley, Dalton C.; Esko, Tõnu; Lehrer, Steven F.; Magnusson, Patrik K. E.; Oskarsson, Sven; Pers, Tune H.; Robinson, Matthew R.; Thom, Kevin; Watson, Chelsea; Chabris, Christopher F.; Meyer, Michelle N.; Laibson, David I.; Yang, Jian; Johannesson, Magnus; Koellinger, Philipp D.; Turley, Patrick; Visscher, Peter M.; Benjamin, Daniel J.; Cesarini, David
Source
Nature Genetics; August 2018, Vol. 50 Issue: 8 p1112-1121, 10p
Subject
Language
ISSN
10614036; 15461718
Abstract
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.