학술논문
Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial
Document Type
Article
Author
Fleischmann, Roy; Mysler, Eduardo; Hall, Stephen; Kivitz, Alan J; Moots, Robert J; Luo, Zhen; DeMasi, Ryan; Soma, Koshika; Zhang, Richard; Takiya, Liza; Tatulych, Svitlana; Mojcik, Christopher; Krishnaswami, Sriram; Menon, Sujatha; Smolen, Josef S; Adams, Luthando; Ally, Mahmood M; du Plooy, Maria C; Louw, Ingrid C; Nayiager, Savithree; Nel, Christoffel B; Nel, Debra; Reuter, Helmuth; Soloman, Ahmed S; Spargo, Catherine E; Hall, Stephen; Rischmueller, Maureen; Sharma, Shunil D; Will, Robert K; Youssef, Peter P; Arroyo, Caroline; Baes, Rosario P; Dulos, Roger B; Hao, Llewellyn T; Lanzon, Allan E; Lichauco, Juan Javier T; Mangubat, Jill H; Ramiterre, Edgar B; Reyes, Bernadette Heizel M; Tan, Perry P; Choe, Jung-Yoon; Kang, Young Mo; Kwon, Seong Ryul; Lee, Sang-Heon; Lee, Shin-Seok; Yoo, Dae-Hyun; Lin, Hsiao-Yi; Luo, Shue-Fen; Tsai, Shih-Tzu; Tsai, Wen-Chan; Tseng, Jui-Cheng; Wei, Cheng-Chung C; Asavatanabodee, Paijit; Nantiruj, Kanokrat; Nilganuwong, Surasak; Uea-Areewongsa, Parichat; Majstorovic, Ljubinka Bozic; Bacic, Suada Mulic; Batalov, Anastas Z; Georgieva-Slavcheva, Gabriela; Mihailova, Mariyana; Nikolov, Nikolay G; Penev, Dimitar P; Spasov, Yuliy A; Stanimirova, Krasimira; Todorov, Stoyan; Toncheva, Antoaneta R; Yordanova, Nadezhda; Mosterova, Zdenka; Novosad, Libor; Prochazkova, Leona; Stehlikova, Helena; Stejfova, Zuzana; Kiseleva, Natalia; Pank, Lea; Savi, Triin; Alexandra, Balbir-Gurman; Amital, Howard; Mevorach, Dror; Rosner, Itzhak A; Mihailova, Anna; Stumbra-Stumberga, Evija; Basijokiene, Vida; Lietuvininkiene, Virginija; Unikiene, Dalia; Brzezicki, Jan; Dudek, Anna M; Glowacka-Kulesz, Maria B; Grabowicz-Wasko, Barbara; Hajduk-Kubacka, Sabina; Hilt, Joanna; Hrycaj, Pawel; Jeka, Slawomir; Kolasa, Renata; Krogulec, Marek; Mastalerz, Hanna; Olak-Popko, Anna; Owczarek, Elzbieta; Ruzga, Zofia; Walczak, Alina; Ancuta, Codrina I; Ancuta, Ioan; Balanescu, Andra R; Berghea, Florian; Bojin, Silvia; Arvunescu, Mihaela A Ianuli; Ionescu, Ruxandra M; Mociran, Eugenia; Pavel, Mariana; Rednic, Simona; Voie, Adriana; Zainea, Carmen M; Bugrova, Olga V; Demin, Alexander; Ershova, Olga B; Gavrisheva, Inna A; Krechikova, Diana G; Kuropatkin, Gennady V; Marusenko, Irina M; Menshikova, Irina V; Noskov, Sergey M; Rebrov, Andrey P; Smakotina, Svetlana A; Yakushin, Sergey S; Zhilyaev, Evgeny; Ramos, Juan Jose Amarelo; Garcia, Francisco Javier Blanco; Nebro, Antonio Fernandez; Esteban, Silvia Perez; Burson, Juan Miguel Sanchez; Sala, Raimon Sanmarti; Ataman, Sebnem; Hizmetli, Sami; Kuru, Omer; Douglas, Karen M; Emery, Paul; Moots, Robert J; Ong, Voon H; Sheeran, Thomas P; Faraawi, Rafat Y; Lessard, Clode; Mendoza, Carlos Abud; Avila-Armengol, Hilario Ernesto; Zapata, Francisco I Avila; Irazoque-Palazuelos, Fedra Consuelo; Cecena, Marco Antonio Maradiaga; Pacheco-Tena, Cesar F; Rizo-Rodriguez, Juan C; Rodriguez-Torres, Isaura M; Aelion, Jacob A; Caciolo, Barbara A; Calmes, James M; Chatpar, Prem; Dayal, Nimesh; De Jesus, Alex; Dikranian, Ara H; Diri, Erdal; Fairfax, Michael J; Fenton, Ira F; Fleischmann, Roy M; Gaylis, Norman B; George, Ronald L; Halter, Dale G; Hernandez, Paul; Hole, Susan A; Hou, Antony C; Huff, John P; Kafaja, Suzanne; Kennedy, Alastair C; Kenney, Howard; Kimmel, Steven C; Kirby, Brian S; Kivitz, Alan J; Legerton, Clarence W; Lindsey, Stephen M; Mallepalli, Jyothi R; Mathews, Steven D; Metyas, Samy K; Mizutani, Wesley T; Najam, Sabeen; Nascimento, Joao M; Pang, Shirley W; Patel, Rakesh C; Poiley, Jeffrey E; Ramirez, Carlos E; Reddy, Riteesha; Rehman, Qaiser; Schnitz, William M; Scoville, Craig D; Shergy, William J; Silverfield, Joel C; Singhal, Atul K; Smallwood-Sherrer, Yvonne R; Songcharoen, Suthin N; Stack, Michael T; Stohl, William; Su, Tien-I K; Udell, James; Waraich, Saleem; Weidmann, Charles E; Wei, Nathan; Wiesenhutter, Craig W; Winkler, Anne E; Zagar, Karen E; Berman, Alberto; Mysler, Eduardo F; Hidalgo, Rodolfo A Pardo; Venarotti, Horacio O; Sariego, Irmgadt Annelise Goecke; Calabresse, Renato E Jimenez; Ruiz-Tagle, Juan Ignacio Vargas; Vargas, Luis Fernando M Bellatin; Berrocal, Alfredo E; Portocarrero, Manuel Gustavo Leon; Jesus, Felix; Pena, Romero
Source
The Lancet; July-August 2017, Vol. 390 Issue: 10093 p457-468, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. The Oral Rheumatoid Arthritis triaL (ORAL) Strategy aimed to assess the comparative efficacy of tofacitinib monotherapy, tofacitinib plus methotrexate, and adalimumab plus methotrexate for the treatment of rheumatoid arthritis in patients with a previous inadequate response to methotrexate.