학술논문
Long-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study
Document Type
Article
Author
Menzies-Gow, Andrew; Wechsler, Michael E; Brightling, Christopher E; Korn, Stephanie; Corren, Jonathan; Israel, Elliot; Chupp, Geoffrey; Bednarczyk, Artur; Ponnarambil, Sandhia; Caveney, Scott; Almqvist, Gun; Gołąbek, Monika; Simonsson, Linda; Lawson, Kaitlyn; Bowen, Karin; Colice, Gene; Hetzel, Jorge Lima; Fiterman, Jussara; Souza Machado, Adelmir; Antila, Martti Anton; Lima, Marina Andrade; Minamoto, Suzana Erico Tanni; Blanco, Daniela Cavalet; Bezerra, Patricia Gomes de Matos; Houle, Pierre-Alain; Lemiere, Catherine; Melenka, Lyle S; Leigh, Richard; Mitchell, Patrick; Anees, Syed; Pek, Bonavuth; Chouinard, Guy; Cheema, Amarjit S; Yang, William Ho-Ching; Philteos, George; Chanez, Pascal; Bourdin, Arnaud; Devouassoux, Gilles; Taille, Camille; De Blay, Frédéric; Leroyer, Christophe; Beurnier, Antoine; Garcia, Gilles; Girodet, Pierre-Olivier; Blanc, François-Xavier; Magnan, Antoine; Wanin, Stéphanie; Just, Jocelyne; Linde, Richard; Zielen, Stefan; Förster, Karin; Geßner, Christian; Jandl, Margret; Buhl, Roland Otto; Korn, Stephanie; Kornmann, Marc Oliver; Linnhoff, Anneliese; Ludwig-Sengpiel, Andrea; Ehlers, Martin; Schmoller, Tibor; Steffen, Heiner; Hoffmann, Martin; Kirschner, Joachim; Schmidt, Olaf; Welte, Tobias; Temme, Hilke; Wand, Ori; Bar-Shai, Amir; Izbicki, Gabriel; Berkman, Neville; Fink, Gershon; Shitrit, David; Adir, Yochai; Kuna, Piotr; Rewerska, Barbara; Pisarczyk-Bogacka, Ewa; Kurbacheva, Oksana; Mikhailov, Sergey L; Vasilev, Maksim; Emelyanov, Alexander; Wali, Siraj; Albanna, Amr; van Zyl-Smit, Richard; Abdullah, Ismail; Abdullah, Ismail; Bernhardi, David; Hoosen, Farzana; Irusen, Elvis; Kalla, Ismail; Lakha, Deepak; Mitha, Essack; Naidoo, Visvakuren; Nell, Haylene; Padayachee, Trevenesan; Reddy, Jeevren; Petrick, Friedrich; van der Walt, Eugene; Vawda, Zubar Fazal Ahmed; Park, Hae-Sim; Lee, Sang Haak; Kim, Mi-Kyeong; Park, Jung-Won; Cho, You Sook; Lee, Byung Jae; Chang, Yoon-Seok; Park, Choon-Sik; Lee, Kwan Ho; Lee, Sook Young; Yoon, HyoungKyu; Sohn, Kyoung Hee; Park, Myung Jae; Min, Kyung Hoon; Cho, Young Joo; Park, Han Ki; Lee, YongChul; Lee, Jaechun; Sheu, Chau-Chyun; Tu, Chih-Yen; Lee, Kang-Yun; Bavbek, Sevim; Gemicioglu, Bilun; Ediger, Dane; Kalkan, Ilkay Koca; Makieieva, Nataliia; Ostrovskyy, Mykola; Dytyatkovs'ka, Yevgeniya; Mostovoy, Yuriy Mykhaylovych; Lebed, Kyrylo; Yakovenko, Oleh; Adams, Atoya; Mooring, Timothy; Torres Jr, Louis; Sexton, Marvin; Thompson, Ernest; Bernstein, Jonathan A; Lisi, Paul; Chappel, Christopher M; Cole, Jeremy; Greenwald, Gary I; Jones, Conigliaro; Klein, Ryan Mitchell; Pham, David N; Spangenthal, Selwyn; Weinstein, Steven F; Windom, Hugh H; Kao, Neil L; Leong, Mila A; Mehta, Vinay; Moore, Wendy C; Bhat, Saligrama; Aish, Bassil; Meltzer, Steven M; Corren, Jonathan; Moss, Mark H; Kerwin, Edward M; Delgado, John Palsted; Lucksinger, Gregg Hudson; Thompson, Charles A; Chupp, Geoffrey; Alpizar, Sady A; Vadgama, Sanjay Virgi; Zafar, Zahid; Jacobs, Joshua S; Lugogo, NJira; Jain, Neal; Sher, Lawrence D; Andrawis, Nabil S; Fuentes, David; Boren, Eric Jason; Gonzalez, Erika G; Talreja, Neetu; Durrani, Sheharyar Sandy; Israel, Elliot; Sekhsaria, Sudhir; DeLeon, Samuel; Shukla, Mayank; Totszollosy Tarpay, Martha M; Fakih, Faisal; Hudes, Golda; Tillinghast, Jeffrey P; Korenblat, Phillip E; Shenoy, Kartik; Que, Loretta; Kureishy, Shahrukh Ahmad; Umeh, Fred Chukwuemeka; Nguyen, Vinh Nhu; Chu, Hanh Thi; Nguyen, Thuy Thi Dieu
Source
The Lancet Respiratory Medicine; May 2023, Vol. 11 Issue: 5 p425-438, 14p
Subject
Language
ISSN
22132600; 22132619
Abstract
Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin. The drug has been tested previously in the phase 3 NAVIGATOR (NCT03347279) and SOURCE (NCT03406078) studies, and was subsequently approved as a treatment for severe asthma. This extension study recruited from NAVIGATOR and SOURCE and aimed to evaluate the long-term safety and efficacy of tezepelumab in individuals with severe, uncontrolled asthma.