학술논문
Variant ABO Blood Group Alleles, Secretor Status, and Risk of Pancreatic Cancer: Results from the Pancreatic Cancer Cohort Consortium.
Document Type
Article
Author
Wolpin, Brian M.; Kraft, Peter; Mousheng Xu; Steplowski, Emily; Olsson, Martin L.; Arslan, Alan A.; Bueno-de-Mesquita, H. Bas; Gross, Myron; Helzlsouer, Kathy; Jacobs, Eric J.; LaCroix, Andrea; Petersen, Gloria; Stolzenberg-Solomon, Rachael Z.; Zheng, Wei; Albanes, Demetrius; Allen, Naomi E.; Amundadottir, Laufey; Austin, Melissa A.; Boutron-Ruault, Marie-Christine; Buring, Julie E.
Source
Cancer Epidemiology, Biomarkers & Prevention; Dec2010, Vol. 19 Issue 12, p3140-3149, 10p, 5 Charts
Subject
Language
ISSN
10559965
Abstract
The article discusses a study which examined ABO blood variants and secretor phenotype from single nucleotide polymorphisms (SNP) in ABO and FUT2 genes. Logistic regression was used to calculate adjusted odds ratios (OR) for pancreatic cancer. Findings suggest that ABO allele subtypes corresponding to increased glucosyltransferase activity were linked with increased risk of pancreatic cancer. Results support the hypothesis on the influence of ABO glycosyltransferase activity on cancer risk.