학술논문
Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial
Document Type
Article
Author
Mok, Tony S K; Wu, Yi-Long; Kudaba, Iveta; Kowalski, Dariusz M; Cho, Byoung Chul; Turna, Hande Z; Castro, Gilberto; Srimuninnimit, Vichien; Laktionov, Konstantin K; Bondarenko, Igor; Kubota, Kaoru; Lubiniecki, Gregory M; Zhang, Jin; Kush, Debra; Lopes, Gilberto; Adamchuk, Grigory; Ahn, Myung-Ju; Alexandru, Aurelia; Altundag, Ozden; Alyasova, Anna; Andrusenko, Orest; Aoe, Keisuke; Araujo, Antonio; Aren, Osvaldo; Arrieta Rodriguez, Oscar; Ativitavas, Touch; Avendano, Oscar; Barata, Fernando; Barrios, Carlos Henrique; Beato, Carlos; Bergstrom, Per; Betticher, Daniel; Bolotina, Larisa; Bondarenko, Igor; Botha, Michiel; Buddu, Sayeuri; Caglevic, Christian; Cardona, Andres; Castro, Gilberto; Castro, Hugo; Cay Senler, Filiz; Cerny, Carlos Alexandre Sydow; Cesas, Alvydas; Chan, Gee-Chen; Chang, Jianhua; Chen, Gongyan; Chen, Xi; Cheng, Susanna; Cheng, Ying; Cherciu, Nelly; Chiu, Chao-Hua; Cho, Byoung Chul; Cicenas, Saulius; Ciurescu, Daniel; Cohen, Graham; Costa, Marcos Andre; Danchaivijitr, Pongwut; De Angelis, Flavia; de Azevedo, Sergio Jobim; Dediu, Mircea; Deliverski, Tsvetan; De Marchi, Pedro Rafael Martins; de The Bustamante Valles, Flor; Ding, Zhenyu; Doganov, Boyan; Dreosti, Lydia; Duarte, Ricardo; Edusma-Dy, Regina; Emelyanov, Sergey; Erman, Mustafa; Fan, Yun; Fein, Luis; Feng, Jifeng; Fenton, David; Fernandes, Gustavo; Ferreira, Carlos; Franke, Fabio Andre; Freitas, Helano; Fujisaka, Yasuhito; Galindo, Hector; Galvez, Christina; Ganea, Doina; Gil, Nuno; Girotto, Gustavo; Goker, Erdem; Goksel, Tuncay; Gomez Aubin, Gonzalo; Gomez Wolff, Luis; Griph, Hakan; Gumus, Mahmut; Hall, Jacqueline; Hart, Gregory; Havel, Libor; He, Jianxing; He, Yong; Hernandez Hernandez, Carlos; Hespanhol, Venceslau; Hirashima, Tomonori; Ho, Chung Man James; Horiike, Atsushi; Hosomi, Yukio; Hotta, Katsuyuki; Hou, Mei; How, Soon Hin; Hsia, Te-Chun; Hu, Yi; Ichiki, Masao; Imamura, Fumio; Ivashchuk, Oleksandr; Iwamoto, Yasuo; Jaal, Jana; Jassem, Jacek; Jordaan, Christa; Juergens, Rosalyn Anne; Kaen, Diego; Kalinka-Warzocha, Ewa; Karaseva, Nina; Karaszewska, Boguslawa; Kazarnowicz, Andrzej; Kasahara, Kazuo; Katakami, Nobuyuki; Kato, Terufumi; Kawaguchi, Tomoya; Kim, Joo Hang; Kishi, Kazuma; Kolek, Vitezslav; Koleva, Marchela; Kolman, Petr; Koubkova, Leona; Kowalyszyn, Ruben; Kowalski, Dariusz; Koynov, Krassimir; Ksienski, Doran; Kubota, Kaoru; Kudaba, Iveta; Kurata, Takayasu; Kuusk, Gerli; Kuzina, Lyudmila; Laczo, Ibolya; Ladrera, Guia Elena Imelda; Laktionov, Konstantin; Landers, Gregory; Lazarev, Sergey; Lerzo, Guillermo; Lesniewski Kmak, Krzysztof; Li, Wei; Liam, Chong Kin; Lifirenko, Igor; Lipatov, Oleg; Liu, Xiaoqing; Liu, Zhe; Lo, Sing Hung; Lopes, Valeria; Lopez, Karla; Lu, Shun; Martinengo, Gaston; Mas, Luis; Matrosova, Marina; Micheva, Rumyana; Milanova, Zhasmina; Miron, Lucian; Mok, Tony; Molina, Matias; Murakami, Shuji; Nakahara, Yasuharu; Nguyen, Tien Quang; Nishimura, Takashi; Ochsenbein, Adrian; Ohira, Tatsuo; Ohman, Ronny; Ong, Choo Khoon; Ostoros, Gyula; Ouyang, Xuenong; Ovchinnikova, Elena; Ozyilkan, Ozgur; Petruzelka, Lubos; Pham, Xuan Dung; Picon, Pablo; Piko, Bela; Poltoratsky, Artem; Ponomarova, Olga; Popelkova, Patrice; Purkalne, Gunta; Qin, Shukui; Ramlau, Rodryg; Rappaport, Bernardo; Rey, Felipe; Richardet, Eduardo; Roubec, Jaromir; Ruff, Paul; Rusyn, Andrii; Saka, Hideo; Salas, Jorge; Sandoval, Mario; Santos, Lucas; Sawa, Toshiyuki; Seetalarom, Kasan; Seker, Mesut; Seki, Nobuhiko; Seolwane, Freddy; Shepherd, Lucinda; Shevnya, Sergii; Shimada, Andrea Kazumi; Shparyk, Yaroslav; Sinielnikov, Ivan; Sirbu, Daniela; Smaletz, Oren; Soares, Joao Paulo Holanda; Sookprasert, Aumkhae; Speranza, Giovanna; Srimuninnimit, Vichien; Sriuranpong, Virote; Stara, Zinaida; Su, Wu-Chou; Sugawara, Shunichi; Szpak, Waldemar; Takahashi, Kazuhisa; Takigawa, Nagio; Tanaka, Hiroshi; Tan Chun Bing, Jerry; Tang, Qiyou; Taranov, Pavel; Tejada, Hermes; Tho, Lye Mun; Torii, Yoshitaro; Trukhyn, Dmytro; Turdean, Maria; Turna, Hande; Ursol, Grygoriy; Vanasek, Jaroslav; Varela, Mirta; Vallejo, Marcela; Vera, Luis; Victorino, Ana-Paula; Vlasek, Tomas; Vynnychenko, Ihor; Wang, Buhai; Wang, Jie; Wang, Kai; Wu, Yilong; Yamada, Kazuhiko; Yang, Chih-Hsin; Yokoyama, Takuma; Yokoyama, Toshihide; Yoshioka, Hiroshige; Yumuk, Fulden; Zambrano, Angela; Zarba, Juan Jose; Zarubenkov, Oleg; Zemaitis, Marius; Zhang, Li; Zhang, Li; Zhang, Xin; Zhao, Jun; Zhou, Caicun; Zhou, Jianying; Zhou, Qing; Zippelius, Alfred
Source
The Lancet; May 2019, Vol. 393 Issue: 10183 p1819-1830, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
First-line pembrolizumab monotherapy improves overall and progression-free survival in patients with untreated metastatic non-small-cell lung cancer with a programmed death ligand 1 (PD-L1) tumour proportion score (TPS) of 50% or greater. We investigated overall survival after treatment with pembrolizumab monotherapy in patients with a PD-L1 TPS of 1% or greater.