학술논문
Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction
Document Type
Article
Author
Source
Molecular Biology of the Cell; June 2012, Vol. 23 Issue: 11 p2131-2142, 12p
Subject
Language
ISSN
10591524; 19394586
Abstract
The Shrm SD2 region contains a core that adopts a novel three-segmented dimer required for Rock binding. Conserved interfaces critical for Rock binding, ppMLC levels, and the formation of contractile cytoskeletal networks are identified. The complex is likely tetrameric, which suggests that conformational changes within SD2 are likely upon Rock binding.