부산대학교 도서관

ObjectivesHypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascenahave been reported. This study, investigated the effect of R. damascenahydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model.MethodsThe rats were divided into control group received just saline; scopolamine group was treated by saline for 2 weeks, but was injected by scopolamine 30 minutes before each trial in Morris water maze test; treatment groups (scopolamine + extract 50; Sco + Ext 50) and (scopolamine + extract 250; Sco + Ext 250) were daily treated by 50 and 250 mg/kg of R. damascenaextract (2 weeks) and were finally injected by scopolamine before each trial in Morris water maze. The brains were removed for biochemical measurements.ResultsTime latency and path length in the scopolamine group were higher than control (P< 0.01 to <0.001). Both treatment groups showed shorter traveled distance and time latency compared with scopolamine group (P< 0.05 to <0.001). Time spent in target quadrant by scopolamine group was lower than control (P< 0.05), while Sco + Ext 250 group spent longer time in target quadrant than scopolamine group (P< 0.05). Malondialdehyde concentrations in hippocampal and cortical tissues of scopolamine group were higher, while thiol concentrations were lower than control ones (P< 0.001). Treatment by both doses of the extract decreased the malondialdehyde concentration, while increased the thiol concentration (P< 0.05 to <0.001).DiscussionThe results of this study showed that the hydroalcoholic extract of R. damascenaprevents scopolamine-induced memory deficits. This finding suggests that memory improvement may be in part due to the antioxidant effects.