학술논문
Impact of CagA Status on Serum Gastrin and Pepsinogen I and II Concentrations in Japanese Children with Helicobacter PyloriInfection
Document Type
Article
Author
Source
Journal of International Medical Research; August 2003, Vol. 31 Issue: 4 p247-252, 6p
Subject
Language
ISSN
03000605; 14732300
Abstract
The study aimed to determine the association between cytotoxin-associated gene product (CagA), serum gastrin and pepsinogen levels in Japanese children infected with Helicobacter pylori.Three hundred children were enrolled in the study. H. pyloriinfection was assessed using an enzyme-linked immunosorbent assay, and CagA status was assessed using immunoblotting. Serum gastrin and pepsinogen concentrations were measured by radioimmunoassay. H. pyloriseroprevalence was 12.3% (37/300) and CagA status was identified in 28/37 H. pylori-seropositive children (75.7%). Serum pepsinogen I and II levels were significantly higher in CagA-seropositive than CagA-seronegative children with H. pyloriinfection. There was no significant relationship between CagA seropositivity and serum gastrin levels. In conclusion, CagA status has a significant impact on serum pepsinogen levels, possibly through enhanced gastric mucosal inflammation.