학술논문
SYNTHESIS OF 5-FLUORO-PRGSTAGLANDINS
Document Type
Article
Source
Chemistry Letters; December 1979, Vol. 8 Issue: 12 p1499-1502, 4p
Subject
Language
ISSN
03667022; 13480715
Abstract
(5E)- And (5Z)-5-fluoro-prostaglandin(PG)F2amethyl esters 1and 2were synthesized via decarboxylative elimination reaction from key intermediate a-fluoro-ß-hydroxy ester 7. 5-Fluoro-6-keto-PGE1methyl ester 3was also synthesized from the key intermediate 7. These 5-fluoro-PGs 1, 2and 3showed interesting biological properties.