학술논문
Roles of protein kinase C and Ca2-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes
Document Type
Article
Author
Source
Journal of Hypertension; April 2001, Vol. 19 Issue: 4 p757-763, 7p
Subject
Language
ISSN
02636352; 14735598
Abstract
We showed that angiotensin II stimulates adrenomedullin production in cultured neonatal rat cardiac myocytes, and that the secreted adrenomedullin inhibits hypertrophy of the myocytes, although the intracellular mechanisms of adrenomedullin production are still unknown. Since protein kinase C (PKC) and the Ca2signaling system are involved in cardiac hypertrophy, we examined the roles of these intracellular signaling systems in the production of adrenomedullin by myocytes.