부산대학교 도서관

This study reveals that young patients with familial hypercholesterolaemia (FH), as compared with individuals without FH, have a higher build-up of coronary artery plaque, linked directly to their increased lifetime exposure to LDL cholesterol.Genetically confirmed FH patients have a higher coronary plaque burden than those without FH, with every 75 mmol/L ∗ years increase in lifetime cumulative LDL cholesterol exposure resulting in a two-fold increase in total plaque volume.Early and potent LDL cholesterol lowering treatments are crucial for FH patients to prevent future cardiovascular diseases.Graphical AbstractCPV, percent calcified plaque volume; NCPV, percent non-calcified plaque volume; PAV, percent atheroma volume; LDL-C, low density lipoprotein cholesterol. Created with BioRender.com