학술논문
IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
Document Type
Article
Source
Molecular Biology of the Cell; March 2012, Vol. 23 Issue: 5 p758-770, 13p
Subject
Language
ISSN
10591524; 19394586
Abstract
IRE1 signaling robustly promoted P23H rhodopsin degradation by both proteasome and lysosome. When one degradation pathway was blocked, IRE1 signaling still promoted misfolded rhodopsin degradation using the remaining pathway. IRE1 signaling reduced levels of other misfolded rhodopsins, with lesser effects on misfolded CFTR.