학술논문
Immunohistochemical Study of Ten Cases of Argyrophilic Carcinoma (Carcinoid) of the Breast
Document Type
Article
Author
Source
Tumori Journal; June 1988, Vol. 74 Issue: 3 p295-302, 8p
Subject
Language
ISSN
03008916; 20382529
Abstract
The significance of argyrophilia in human breast cancer is still a controversial issue. We tested immunohistochemically 10 cases of argyrophilic carcinomas of the breast and found evidence of immunoreactivity with neuroendocrine markers: chromogranin, NSE, gastrin, insulin and bombesin. Argyrophilia was demonstrated in breast cancers of the usual types and was found to be related to the secretory activity of neoplastic cells. Unfortunately, no adequate follow-up data are available to clarify the natural history of argyrophilic breast cancer. A clinical treatment different from that of conventional breast cancer is not at present justified.