학술논문
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.
Document Type
Article
Author
Source
The Journal of Experimental Medicine; December 1990, Vol. 172 Issue: 6 p1571-1575, 5p
Subject
Language
ISSN
00221007; 15409538
Abstract
Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RAR alpha gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RAR alpha gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.