학술논문
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
Document Type
Article
Author
de Vries, Paul S.; Reventun, Paula; Brown, Michael R.; Heath, Adam S.; Huffman, Jennifer E.; Le, Ngoc-Quynh; Bebo, Allison; Brody, Jennifer A.; Temprano-Sagrera, Gerard; Raffield, Laura M.; Ozel, Ayse Bilge; Thibord, Florian; Jain, Deepti; Lewis, Joshua P.; Rodriguez, Benjamin A. T.; Pankratz, Nathan; Taylor, Kent D.; Polasek, Ozren; Chen, Ming-Huei; Yanek, Lisa R.; Carrasquilla, German D.; Marioni, Riccardo E.; Kleber, Marcus E.; Trégouët, David-Alexandre; Yao, Jie; Li-Gao, Ruifang; Joshi, Peter K.; Trompet, Stella; Martinez-Perez, Angel; Ghanbari, Mohsen; Howard, Tom E.; Reiner, Alex P.; Arvanitis, Marios; Ryan, Kathleen A.; Bartz, Traci M.; Rudan, Igor; Faraday, Nauder; Linneberg, Allan; Ekunwe, Lynette; Davies, Gail; Delgado, Graciela E.; Suchon, Pierre; Guo, Xiuqing; Rosendaal, Frits R.; Klaric, Lucija; Noordam, Raymond; van Rooij, Frank; Curran, Joanne E.; Wheeler, Marsha M.; Osburn, William O.; O'Connell, Jeffrey R.; Boerwinkle, Eric; Beswick, Andrew; Psaty, Bruce M.; Kolcic, Ivana; Souto, Juan Carlos; Becker, Lewis C.; Hansen, Torben; Doyle, Margaret F.; Harris, Sarah E.; Moissl, Angela P.; Deleuze, Jean-François; Rich, Stephen S.; van Hylckama Vlieg, Astrid; Campbell, Harry; Stott, David J.; Soria, Jose Manuel; de Maat, Moniek P. M.; Almasy, Laura; Brody, Lawrence C.; Auer, Paul L.; Abe, Namiko; Abecasis, Gonçalo; Aguet, Francois; Albert, Christine; Almasy, Laura; Alonso, Alvaro; Ament, Seth; Anderson, Peter; Anugu, Pramod; Applebaum-Bowden, Deborah; Ardlie, Kristin; Arking, Dan; Arnett, Donna K; Ashley-Koch, Allison; Aslibekyan, Stella; Assimes, Tim; Auer, Paul; Avramopoulos, Dimitrios; Ayas, Najib; Balasubramanian, Adithya; Barnard, John; Barnes, Kathleen; Barr, R. Graham; Barron-Casella, Emily; Barwick, Lucas; Beaty, Terri; Beck, Gerald; Becker, Diane; Becker, Lewis; Beer, Rebecca; Beitelshees, Amber; Benjamin, Emelia; Benos, Takis; Bezerra, Marcos; Bielak, Larry; Bis, Joshua; Blackwell, Thomas; Blangero, John; Blue, Nathan; Boerwinkle, Eric; Bowden, Donald W.; Bowler, Russell; Brody, Jennifer; Broeckel, Ulrich; Broome, Jai; Brown, Deborah; Bunting, Karen; Burchard, Esteban; Bustamante, Carlos; Buth, Erin; Cade, Brian; Cardwell, Jonathan; Carey, Vincent; Carrier, Julie; Carson, April P.; Carty, Cara; Casaburi, Richard; Casas Romero, Juan P; Casella, James; Castaldi, Peter; Chaffin, Mark; Chang, Christy; Chang, Yi-Cheng; Chasman, Daniel; Chavan, Sameer; Chen, Bo-Juen; Chen, Wei-Min; Ida Chen, Yii-Der; Cho, Michael; Choi, Seung Hoan; Chuang, Lee-Ming; Chung, Mina; Chung, Ren-Hua; Clish, Clary; Comhair, Suzy; Conomos, Matthew; Cornell, Elaine; Correa, Adolfo; Crandall, Carolyn; Crapo, James; Cupples, L. Adrienne; Curran, Joanne; Curtis, Jeffrey; Custer, Brian; Damcott, Coleen; Darbar, Dawood; David, Sean; Davis, Colleen; Daya, Michelle; de Andrade, Mariza; de las Fuentes, Lisa; de Vries, Paul; DeBaun, Michael; Deka, Ranjan; DeMeo, Dawn; Devine, Scott; Dinh, Huyen; Doddapaneni, Harsha; Duan, Qing; Dugan-Perez, Shannon; Duggirala, Ravi; Durda, Jon Peter; Dutcher, Susan K.; Eaton, Charles; Ekunwe, Lynette; El Boueiz, Adel; Ellinor, Patrick; Emery, Leslie; Erzurum, Serpil; Farber, Charles; Farek, Jesse; Fingerlin, Tasha; Flickinger, Matthew; Fornage, Myriam; Franceschini, Nora; Frazar, Chris; Fu, Mao; Fullerton, Stephanie M.; Fulton, Lucinda; Gabriel, Stacey; Gan, Weiniu; Gao, Shanshan; Gao, Yan; Gass, Margery; Geiger, Heather; Gelb, Bruce; Geraci, Mark; Germer, Soren; Gerszten, Robert; Ghosh, Auyon; Gibbs, Richard; Gignoux, Chris; Gladwin, Mark; Glahn, David; Gogarten, Stephanie; Gong, Da-Wei; Goring, Harald; Graw, Sharon; Gray, Kathryn J.; Grine, Daniel; Gross, Colin; Gu, C. Charles; Guan, Yue; Guo, Xiuqing; Gupta, Namrata; Haessler, Jeff; Hall, Michael; Han, Yi; Hanly, Patrick; Harris, Daniel; Hawley, Nicola L.; He, Jiang; Heavner, Ben; Heckbert, Susan; Hernandez, Ryan; Herrington, David; Hersh, Craig; Hidalgo, Bertha; Hixson, James; Hobbs, Brian; Hokanson, John; Hong, Elliott; Hoth, Karin; Hsiung, Chao (Agnes); Hu, Jianhong; Hung, Yi-Jen; Huston, Haley; Hwu, Chii Min; Irvin, Marguerite Ryan; Jackson, Rebecca; Jain, Deepti; Jaquish, Cashell; Johnsen, Jill; Johnson, Andrew; Johnson, Craig; Johnston, Rich; Jones, Kimberly; Kang, Hyun Min; Kaplan, Robert; Kardia, Sharon; Kelly, Shannon; Kenny, Eimear; Kessler, Michael; Khan, Alyna; Khan, Ziad; Kim, Wonji; Kimoff, John; Kinney, Greg; Konkle, Barbara; Kooperberg, Charles; Kramer, Holly; Lange, Christoph; Lange, Ethan; Lange, Leslie; Laurie, Cathy; Laurie, Cecelia; LeBoff, Meryl; Lee, Jiwon; Lee, Sandra; Lee, Wen-Jane; LeFaive, Jonathon; Levine, David; Levy, Dan; Lewis, Joshua; Li, Xiaohui; Li, Yun; Lin, Henry; Lin, Honghuang; Lin, Xihong; Liu, Simin; Liu, Yongmei; Liu, Yu; Loos, Ruth J. F.; Lubitz, Steven; Lunetta, Kathryn; Luo, James; Magalang, Ulysses; Mahaney, Michael; Make, Barry; Manichaikul, Ani; Manning, Alisa; Manson, JoAnn; Martin, Lisa; Marton, Melissa; Mathai, Susan; Mathias, Rasika; May, Susanne; McArdle, Patrick; McDonald, Merry-Lynn; McFarland, Sean; McGarvey, Stephen; McGoldrick, Daniel; McHugh, Caitlin; McNeil, Becky; Mei, Hao; Meigs, James; Menon, Vipin; Mestroni, Luisa; Metcalf, Ginger; Meyers, Deborah A; Mignot, Emmanuel; Mikulla, Julie; Min, Nancy; Minear, Mollie; Minster, Ryan L; Mitchell, Braxton D.; Moll, Matt; Momin, Zeineen; Montasser, May E.; Montgomery, Courtney; Muzny, Donna; Mychaleckyj, Josyf C; Nadkarni, Girish; Naik, Rakhi; Naseri, Take; Natarajan, Pradeep; Nekhai, Sergei; Nelson, Sarah C.; Neltner, Bonnie; Nessner, Caitlin; Nickerson, Deborah; Nkechinyere, Osuji; North, Kari; O'Connell, Jeff; O'Connor, Tim; Ochs-Balcom, Heather; Okwuonu, Geoffrey; Pack, Allan; Paik, David T.; Palmer, Nicholette; Pankow, James; Papanicolaou, George; Parker, Cora; Peloso, Gina; Peralta, Juan Manuel; Perez, Marco; Perry, James; Peters, Ulrike; Peyser, Patricia; Phillips, Lawrence S; Pleiness, Jacob; Pollin, Toni; Post, Wendy; Becker, Julia Powers; Boorgula, Meher Preethi; Preuss, Michael; Psaty, Bruce; Qasba, Pankaj; Qiao, Dandi; Qin, Zhaohui; Rafaels, Nicholas; Raffield, Laura; Rajendran, Mahitha; Ramachandran, Vasan S.; Rao, D. C.; Rasmussen-Torvik, Laura; Ratan, Aakrosh; Redline, Susan; Reed, Robert; Reeves, Catherine; Regan, Elizabeth; Reiner, Alex; Reupena, Muagututi‘a Sefuiva; Rice, Ken; Rich, Stephen; Robillard, Rebecca; Robine, Nicolas; Roden, Dan; Roselli, Carolina; Rotter, Jerome; Ruczinski, Ingo; Runnels, Alexi; Russell, Pamela; Ruuska, Sarah; Ryan, Kathleen; Sabino, Ester Cerdeira; Saleheen, Danish; Salimi, Shabnam; Salvi, Sejal; Salzberg, Steven; Sandow, Kevin; Sankaran, Vijay G.; Santibanez, Jireh; Schwander, Karen; Schwartz, David; Sciurba, Frank; Seidman, Christine; Seidman, Jonathan; Sériès, Frédéric; Sheehan, Vivien; Sherman, Stephanie L.; Shetty, Amol; Shetty, Aniket; Hui-Heng Sheu, Wayne; Shoemaker, M. Benjamin; Silver, Brian; Silverman, Edwin; Skomro, Robert; Smith, Albert Vernon; Smith, Jennifer; Smith, Josh; Smith, Nicholas; Smith, Tanja; Smoller, Sylvia; Snively, Beverly; Snyder, Michael; Sofer, Tamar; Sotoodehnia, Nona; Stilp, Adrienne M.; Storm, Garrett; Streeten, Elizabeth; Su, Jessica Lasky; Sung, Yun Ju; Sylvia, Jody; Szpiro, Adam; Taliun, Daniel; Tang, Hua; Taub, Margaret; Taylor, Kent D.; Taylor, Matthew; Taylor, Simeon; Telen, Marilyn; Thornton, Timothy A.; Threlkeld, Machiko; Tinker, Lesley; Tirschwell, David; Tishkoff, Sarah; Tiwari, Hemant; Tong, Catherine; Tracy, Russell; Tsai, Michael; Vaidya, Dhananjay; Van Den Berg, David; VandeHaar, Peter; Vrieze, Scott; Walker, Tarik; Wallace, Robert; Walts, Avram; Wang, Fei Fei; Wang, Heming; Wang, Jiongming; Watson, Karol; Watt, Jennifer; Weeks, Daniel E.; Weinstock, Joshua; Weir, Bruce; Weiss, Scott T; Weng, Lu-Chen; Wessel, Jennifer; Willer, Cristen; Williams, Kayleen; Williams, L. Keoki; Wilson, Carla; Wilson, James; Winterkorn, Lara; Wong, Quenna; Wu, Joseph; Xu, Huichun; Yanek, Lisa; Yang, Ivana; Yu, Ketian; Zekavat, Seyedeh Maryam; Zhang, Yingze; Zhao, Snow Xueyan; Zhao, Wei; Zhu, Xiaofeng; Ziv, Elad; Zody, Michael; Zoellner, Sebastian; Lindstrom, Sara; Wang, Lu; Smith, Erin N.; Gordon, William; van Hylckama Vlieg, Astrid; de Andrade, Mariza; Brody, Jennifer A.; Pattee, Jack W.; Haessler, Jeffrey; Brumpton, Ben M.; Chasman, Daniel I.; Suchon, Pierre; Chen, Ming-Huei; Turman, Constance; Germain, Marine; Wiggins, Kerri L.; MacDonald, James; Braekkan, Sigrid K.; Armasu, Sebastian M.; Pankratz, Nathan; Jackson, Rabecca D.; Nielsen, Jonas B.; Giulianini, Franco; Puurunen, Marja K.; Ibrahim, Manal; Heckbert, Susan R.; Bammler, Theo K.; Frazer, Kelly A.; McCauley, Bryan M.; Taylor, Kent; Pankow, James S.; Reiner, Alexander P.; Gabrielsen, Maiken E.; Deleuze, Jean-François; O'Donnell, Chris J.; Kim, Jihye; McKnight, Barbara; Kraft, Peter; Hansen, John-Bjarne; Rosendaal, Frits R.; Heit, John A.; Psaty, Bruce M.; Tang, Weihong; Kooperberg, Charles; Hveem, Kristian; Ridker, Paul M.; Morange, Pierre-Emmanuel; Johnson, Andrew D.; Kabrhel, Christopher; AlexandreTrégouët, David; Smith, Nicholas L.; Mitchell, Braxton D.; Ben-Shlomo, Yoav; Fornage, Myriam; Hayward, Caroline; Mathias, Rasika A.; Kilpeläinen, Tuomas O.; Lange, Leslie A.; Cox, Simon R.; März, Winfried; Morange, Pierre-Emmanuel; Rotter, Jerome I.; Mook-Kanamori, Dennis O.; Wilson, James F.; van der Harst, Pim; Jukema, J. Wouter; Ikram, M. Arfan; Blangero, John; Kooperberg, Charles; Desch, Karl C.; Johnson, Andrew D.; Sabater-Lleal, Maria; Lowenstein, Charles J.; Smith, Nicholas L.; Morrison, Alanna C.
Source
Blood; May 2024, Vol. 143 Issue: 18 p1845-1855, 11p
Subject
Language
ISSN
00064971; 15280020
Abstract
•We identified 7 new genetic regions for factor VIII levels, 1 for von Willebrand factor levels, and 3 in a combined analysis.•Silencing B3GNT2and CD36reduced factor VIII release in vitro.Silencing B3GNT2, CD36, and PDIA3reduced von Willebrand factor release.