학술논문
Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data
Document Type
Article
Author
Campbell, Bruce C V; Ma, Henry; Ringleb, Peter A; Parsons, Mark W; Churilov, Leonid; Bendszus, Martin; Levi, Christopher R; Hsu, Chung; Kleinig, Timothy J; Fatar, Marc; Leys, Didier; Molina, Carlos; Wijeratne, Tissa; Curtze, Sami; Dewey, Helen M; Barber, P Alan; Butcher, Kenneth S; De Silva, Deidre A; Bladin, Christopher F; Yassi, Nawaf; Pfaff, Johannes A R; Sharma, Gagan; Bivard, Andrew; Desmond, Patricia M; Schwab, Stefan; Schellinger, Peter D; Yan, Bernard; Mitchell, Peter J; Serena, Joaquín; Toni, Danilo; Thijs, Vincent; Hacke, Werner; Davis, Stephen M; Donnan, Geoffrey A; Donnan, Geoffrey A.; Davis, Stephen M.; Ma, Henry; Campbell, Bruce C.V.; Churilov, Leonid; Parsons, Mark W.; Yan, Bernard; Mitchell, Peter J.; Yassi, Nawaf; Sharma, Gagan; Desmond, Patricia M.; Oxley, Thomas; Wu, Teddy Y.; Shah, Darshan; Zhao, Henry; Rodrigues, Edrich; Salvaris, Patrick; Alemseged, Fana; Ng, Felix; Williams, Cameron; Ng, Jo-Lyn; Tu, Hans T-H.; McDonald, Amy; Jackson, David; Tsoleridis, Jessica; McCoy, Rachael; Pesavento, Lauren; Weir, Louise; Bivard, Andrew; Kleinig, Timothy J.; Patel, S.; Harvey, J.; Mahadevan, J.; Cheong, E.; Balabanski, Anna; Waters, Michael; Drew, Roy; Cranefield, Jennifer; Wijeratne, Tissa; Mackey, Elizabeth; Celestino, Sherisse; Low, Essie; Dewey, Helen M.; Bladin, Christopher F.; Loh, Poh Sien; Choi, Philip M.; Coote, Skye; Frost, Tanya; Hogan, K.; Ding, C.; McModie, S.; Zhang, W.W.; Kyndt, Christopher; Moore, A.; Ross, Z.; Liu, J.; Miteff, Ferdinand; Levi, Christopher R.; Ang, Timothy; Spratt, Neil; Garcia-Esperon, Carlos; Kaauwai, Lara; Phan, Thanh G.; Ly, John; Singhal, Shaloo; Clissold, Benjamin; Wong, Kitty; Krause, Martin; Day, Susan; Sturm, Jonathan; O'Brian, Bill; Grimley, Rohan; Thijs, Vincent; Simpson, Marion; Lee-Archer, Matthew; Brodtmann, Amy; Coulton, Bronwyn; Young, Dennis; Wong, Andrew A.; Muller, Claire; Field, Deborah K.; Vallat, W.; Maxwell, Vanessa; Bailey, Peter; Sabet, Arman; Mishra, Sachin; Tan, Meng; George, K.; Barber, P. Alan; Zhao, L.; Meretoja, Atte; Curtze, Sami; Tatlisumak, Turgut; Sibolt, G.; Tiainen, M.; Koivu, M.; Aarnio, K.; Virta, J.; Kasari, O.; Eirola, S.; Sun, M.C.; Chen, T.C.; Chuang, C.S.; Chen, Y.Y.; Lin, C.M.; Ho, S.C.; Hsiao, P.M.; Tsai, C.H.; Huang, W.S.; Yang, Y.W.; Huang, H.Y.; Wang, W.C.; Liu, C.H.; Lu, M.K.; Lu, C.H.; Kung, W.L.; Jiang, S.K.; Wu, Y.H.; Huang, S.C.; Tseng, C.H.; Tseng, L.T.; Guo, Y.C.; Lin, D.; Hsu, C.T.; Kuan, C.W.; Hsu, J.P.; Tsai, H.T.; Suzuki, M.; Sun, Y.; Chen, H.F.; Lu, C.J.; Lin, C.H.; Huang, C.C.; Chu, H.J.; Lee, C.Y.; Chang, W.H.; Lo, Y.C.; Hsu, Y.T.; Chen, C.H.; Sung, P.S.; Ysai, C.L.; Jeng, J.S.; Tang, S.C.; Tsai, L.K.; Yeh, S.J.; Lee, Y.C.; Wang, Y.T.; Chung, T.C.; Hu, C.J.; Chan, L.; Chiou, Y.W.; Lien, L.M.; Yeh, H.L.; Yeh, J.H.; Chen, W.H.; Lau, C.L.; Chang, A.; Lee, I.Y.; Huang, M.Y.; Lee, J.T.; Peng, G.S.; Lim, J.C.; Hsu, Y.D.; Lin, C.C.; Cheng, C.A.; Yen, C.H.; Yang, F.C.; Hsu, C.H.; Sung, Y.F.; Tsai, C.K.; Tsai, C.L.; Hsiao, P.M.; Lee, A.; Hankey, Graeme; Blacker, David; Gerraty, Richard; Chen, C-I.; Hsu, C-S.; Cowley, Elise; McCoy, Rachael; Sallaberger, Michele; Snow, Barry; Kolbe, John; Stark, Richard; King, John; Macdonnell, Richard; Attia, John; D'Este, Catherine; Bernhardt, Julie; Carey, Leeanne; Cadilhac, Dominique; Anderson, Craig; Howells, David; Barber, A.; Connelly, Alan; Macleod, Malcolm; O'Collins, Victoria; Wilson, W.; Macaulay, L.; Bendszus, Martin; Bluhmki, Erich; Eschenfelder, Christoph; Hacke, Werner; Molina, Carlos; Leys, Didier; Ringleb, Peter; Schellinger, Peter; Schwab, Stefan; Toni, Danilo; Wahlgren, Nils; Wardlaw, Joanna; Oppenheim, Catherine; Lees, Kennedy R.; Kaste, Markku; von Kummer, Rüdiger; Chatellier, Gilles; Laage, Rico; Nuñez, Xavier; Ehrenkrona, Christina; Svenson, Ann-Sofie; Cove, Lynda; Niederkorn, Kurt; Gruber, Franz; Kapeller, Peter; Mikulik, Robert; Mas, Jean-Louis; Berrouschot, Jörg; Sobesky, Jan; Köhrmann, Martin; Steiner, Thorsten; Kessler, Christof; Fatar, Marc; Dziewas, Rainer; Poli, Sven; Althaus-Knaurer, Katharina; Bovi, Paolo; Rodriguez, Alain L.; Arenillas, Juan F.; Muir, Keith; Veltkamp, Roland; Dixit, Anand; Muddegowda, Girish; Kala, Lalit; De Silva, Deidre A.; Butcher, Kenneth S.; Byrnes, G.; Peeters, Andre; Chalk, J.B.; Fink, John N.; Kimber, Thomas E.; Schultz, David; Hand, Peter J.; Frayne, Judith; Tress, Brian M.; McNeil, John; Burns, R.; Johnston, C.; Williams, M.
Source
The Lancet; July 2019, Vol. 394 Issue: 10193 p139-147, 9p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Stroke thrombolysis with alteplase is currently recommended 0–4·5 h after stroke onset. We aimed to determine whether perfusion imaging can identify patients with salvageable brain tissue with symptoms 4·5 h or more from stroke onset or with symptoms on waking who might benefit from thrombolysis.