부산대학교 도서관

In studies which involved the administration of 1-Gm. doses of nalidixic acid to human volunteers four times daily for a period of 10days, it has been shown that the resulting plasma levels of nalidixic and of hydroxynalidixic acid could be predicted reasonably well from a model derived from single-dose studies. More satisfactory blood levels are obtained if the doses are taken at least 1hr. before meals. Repeated dosage results in no important change in the absorption-excretion-metabolism patterns of the drug.