학술논문
Animal models for hormone-dependent human breast cancer
Document Type
Article
Source
Cancer Chemotherapy and Pharmacology; January 1984, Vol. 12 Issue: 1 p13-17, 5p
Subject
Language
ISSN
03445704; 14320843
Abstract
The present study shows that canine and feline mammary tumors, like human breast tumors, can be polyreceptive, i.e., they can contain estrogen (ER), progestin (PR), androgen, glucocorticoid, and/or mineralocorticoid cytosol receptors. Furthermore, a follow-up of 45 bitches with mammary carcinoma has indicated that the survival rate is significantly higher in animals with receptor-rich (ER and/or PR) tumors. This indicates that these canine mammary tumors should be evaluated further for their suitability as an animal model for hormone-dependent human breast carcinoma.