학술논문
Central nervous system active compounds. IV. Synthesis of 3-aminobenzylphthalides
Document Type
Article
Author
Source
Australian Journal of Chemistry; 1980, Vol. 33 Issue: 12 p2699-2715, 17p
Subject
Language
ISSN
00049425; 14450038
Abstract
Several 3-aminobenzylphthalides have been prepared by reactions of 3- (2-oxo-1-phenylpropyl)-phthalides with hydrazoic acid or by the Beckmann rearrangement. The corresponding reactions with 3-(2- oxoindanyl)phthalides showed limited success but led to a new synthesis of phthalide-isoquinoline alkaloids. Preliminary biological testing of some of these derivatives indicates that they only have weak central nervous system activity.