학술논문
TRPM Channels Phosphorylation as a Potential Bridge Between Old Signals and Novel Regulatory Mechanisms of Insulin Secretion
Document Type
Article
Source
Current Diabetes Reviews; March 2013, Vol. 9 Issue: 2 p117-125, 9p
Subject
Language
ISSN
15733998
Abstract
Transient receptor potential channels, especially the members of the melastatin family (TRPM), participate in insulin secretion. Some of them are substrates for protein kinases, which are involved in several neurotransmitter, incretin and hormonal signaling cascades in cells. The functional relationships between protein kinases and TRPM channels in systems of heterologous expression and native tissues rise issues about novel regulation pathways of pancreatic -cell excitability. The aim of the present work is to review the evidences about phosphorylation of TRPM channels in cells and to discuss the perspectives on insulin secretion.