학술논문
Protection Induced in Mice Vaccinated with Recombinant Collagen‐Binding Protein (CnBP) and Alpha‐Toxoid against Intramammary Infection with Staphylococcus aureus
Document Type
Article
Source
Microbiology and Immunology; May 2000, Vol. 44 Issue: 5 p381-384, 4p
Subject
Language
ISSN
03855600; 13480421
Abstract
Mice vaccinated with a combination of two Staphylococcus aureusantigens consisting of a recombinant collagen‐binding protein (CnBP) and alpha‐toxoid (α‐toxoid) were significantly protected from intramammary challenge infection with S. aureus. The average number of bacteria recovered from the glands of mice vaccinated with the combination of CnBP/α‐toxoid was significantly lower compared to the average number of bacteria recovered from the glands of mice vaccinated with only CnBP or α‐toxoid or controls (P≤ 0.01). Histopathological examination of mammary glands of mice vaccinated with CnBP together with α‐toxoid showed no pathological changes, whereas glands of mice vaccinated with CnBP or α‐toxoid alone developed severe mastitis and showed both focal and disseminated necrosis.