학술논문
Effector Memory–Expressing CD45RA (TEMRA) CD8+T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses
Document Type
Article
Author
Doan Ngoc, Tra-My; Tilly, Gaëlle; Danger, Richard; Bonizec, Orianne; Masset, Christophe; Guérif, Pierrick; Bruneau, Sarah; Glemain, Alexandre; Harb, Jean; Cadoux, Marion; Vivet, Anaïs; Mai, Hoa Le; Garcia, Alexandra; Laplaud, David; Liblau, Roland; Giral, Magali; Blandin, Stéphanie; Feyeux, Magalie; Dubreuil, Laurence; Pecqueur, Claire; Cyr, Matthew; Ni, Weiming; Brouard, Sophie; Degauque, Nicolas; Blancho, Gilles; Branchereau, Julien; Cantarovich, Diego; Chapelet, Agnès; Dantal, Jacques; Deltombe, Clément; Figueres, Lucile; Garandeau, Claire; Giral, Magali; Gourraud-Vercel, Caroline; Hourmant, Maryvonne; Karam, Georges; Kerleau, Clarisse; Masset, Christophe; Kervela, Delphine; Lebot, Sabine; Meurette, Aurélie; Ville, Simon; Kandell, Christine; Moreau, Anne; Renaudin, Karine; Cesbron, Anne; Delbos, Florent; Walencik, Alexandre; Devis, Anne
Source
Journal of the American Society of Nephrology; December 2022, Vol. 33 Issue: 12 p2211-2231, 21p
Subject
Language
ISSN
10466673; 15333450
Abstract
The pathogenic role of terminally differentiated effector memory (TEMRA) CD8+T cells has been implicated in kidney transplant failure. The authors showed that humoral rejection of kidney allografts is associated with an accumulation of cytolytic TEMRA CD8+T cells in blood and in kidney graft biopsies. They demonstrated that TEMRA CD8+T cells from kidney transplant recipients exhibit enhanced migratory properties compared with effector memory CD8+T cells and that the chemokine CXCL12 not only promotes migration of TEMRA CD8+T cells toward nonlymphoid organs but also triggers a purinergic P2X4 receptor–dependent proinflammatory response. They also found that agents aimed at potential TEMRA CD8+T cell–specific targets inhibited the migration of TEMRA CD8+T cells from kidney transplant recipients, suggesting a possible strategy in treating kidney transplant failure.