학술논문
An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial
Document Type
Article
Author
Bornstein, Natan M; Saver, Jeffrey L; Diener, Hans Christoph; Gorelick, Philip B; Shuaib, Ashfaq; Solberg, Yoram; Thackeray, Lisa; Savic, Milan; Janelidze, Tamar; Zarqua, Natia; Yarnitsky, David; Molina, Carlos A; Shuaib, Ashfaq; Hill, Michael; Vaclavik, Daniel; Skoloudik, David; Fiksa, Jan; Andersen, Grethe; Jakala, Pekka; Tatlisumak, Turgut; Kuzmanovski, Igor; Guillon, Benoit; Chabriat, Hugues; Mahagne, Marie Helene; Timsit, Serge; Ronziere, Thomas; Ingorokva, Gocha; Beridze, Maya; Beridze, Mzia; Zarqua, Natia; Kharaishvili, Nino; Kakabadze, Nodar; Janelidze, Tamar; Griewing, Bernd; Hobohm, Carsten; Schneider, Dietmar; Weimar, Christian; Poppert, Holger; Kimmig, Hubert; Berrouschot, Joerg; Ringleb, Peter; Schwab, Stefan; Kohrmann, Martin; Kallmunzer, Bernd; Kollmar, Rainer; Endres, Matthias; Hausler, Karl-Georg; Cheung, Raymond; Wai Hong Leung, Thomas; Dorodnicov, Elena; Halevi, Hen; Auriel, Eitan; Streifler, Jonathan; Leker, Ronen; Schwammenthal, Yvonne; Toni, Danilo; Agnelli, Giancarlo; Caso, Valeria; Słowik, Agnieszka; Czlonkowska, Anna; Lubinski, Ignacy; Kochanowicz, Jan; Sobolewski, Piotr; Brola, Waldemar; Salgado, Antonio Vasco; Correia, Carlos; Azevedo, Elsa; Roriz, Jose; Zarkov, Marija; Savic, Milan; Petrovic, Zarko; Krastev, Georgi; Dvorak, Miloslav; Rodriguez Campello, Ana; Nunez, Antonio Gil; Molina, Carlos; Purroy, Francisco; Marti-Fabregas, Joan; Arenillas, Juan; Alonso, Maria; Cardona, Pedro; Blanco Gonzalez, Miguel; Tur, Silvia; Segura Martin, Tomas; Anzhelika, Payenok; Shownkeen, Harish; Concha, Mauricio; Sethi, Pramod; Sen, Souvik; Zaidi, Syed; Zaidi, Syed; Devlin, Thomas
Source
The Lancet; July 2019, Vol. 394 Issue: 10194 p219-229, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Sphenopalatine ganglion stimulation increased cerebral collateral blood flow, stabilised the blood–brain barrier, and reduced infarct size, in preclinical models of acute ischaemic stroke, and showed potential benefit in a pilot randomised trial in humans. The pivotal ImpACT-24B trial aimed to determine whether sphenopalatine ganglion stimulation 8–24 h after acute ischaemic stroke improved functional outcome.