학술논문
APOEepsilon variation in multiple sclerosis susceptibility and disease severity
Document Type
Article
Author
Burwick, R M.; Ramsay, P P.; Haines, J L.; Hauser, S L.; Oksenberg, J R.; Pericak-Vance, M A.; Schmidt, S; Compston, A; Sawcer, S; Cittadella, R; Savettieri, G; Quattrone, A; Polman, C H.; Uitdehaag, B M.J.; Zwemmer, J N.P.; Hawkins, C P.; Ollier, W E.R.; Weatherby, S; Enzinger, C; Fazekas, F; Schmidt, H; Schmidt, R; Hillert, J; Masterman, T; Hogh, P; Niino, M; Kikuchi, S; Maciel, P; Santos, M; Rio, M E.; Kwiecinski, H; Zakrzewska-Pniewska, B; Evangelou, N; Palace, J; Barcellos, L F.
Source
Neurology (Ovid); May 2006, Vol. 66 Issue: 9 p1373-1383, 11p
Subject
Language
ISSN
00283878; 1526632X
Abstract
Previous studies have examined the role of APOEvariation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and families genotyped for the APOEepsilon polymorphism.