학술논문
Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial
Document Type
Article
Author
Townsend, Raymond R; Mahfoud, Felix; Kandzari, David E; Kario, Kazuomi; Pocock, Stuart; Weber, Michael A; Ewen, Sebastian; Tsioufis, Konstantinos; Tousoulis, Dimitrios; Sharp, Andrew S P; Watkinson, Anthony F; Schmieder, Roland E; Schmid, Axel; Choi, James W; East, Cara; Walton, Anthony; Hopper, Ingrid; Cohen, Debbie L; Wilensky, Robert; Lee, David P; Ma, Adrian; Devireddy, Chandan M; Lea, Janice P; Lurz, Philipp C; Fengler, Karl; Davies, Justin; Chapman, Neil; Cohen, Sidney A; DeBruin, Vanessa; Fahy, Martin; Jones, Denise E; Rothman, Martin; Böhm, Michael; Aoki, Jiro; Batson, Bryan; Böhm, Michael; Choi, James W; Cohen, Debbie L; Dangas, George; David, Shukri; Davies, Justin; Devireddy, Chandan M; Kandzari, David; Kario, Kazuomi; Lee, David P; Lurz, Philipp C; Patel, Manesh; Patel, Kiritkumar; Schmieder, Roland E; Sharp, Andrew S P; Singh, Jasvindar; Tsioufis, Konstantinos; Walton, Anthony; Weber, Thomas; Weil, Joachim; Zeller, Thomas; Ziada, Khaled; Tanabe, Kengo; Wilkins, Robert; Mahfoud, Felix; East, Cara; Wilensky, Robert; Contreras, Johanna; Steigerwalt, Susan; Chapman, Neil; Lea, Janice P; Reedus, Denise; Hoshide, Satoshi; Ma, Adrian; Fengler, Karl; Svetkey, Laura; Rao, Anjani; Schmid, Axel; Watkinson, Anthony F; Brown, Angela; Tousoulis, Dimitrios; Hopper, Ingrid; Suppan, Markus; Agdirlioglu, Tolga; Noory, Elias; Chasen, Craig
Source
The Lancet; November 2017, Vol. 390 Issue: 10108 p2160-2170, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Previous randomised renal denervation studies did not show consistent efficacy in reducing blood pressure. The objective of our study was to evaluate the effect of renal denervation on blood pressure in the absence of antihypertensive medications.