학술논문
MODERATED POSTER SESSION: Imaging in interventional cardiology: Wednesday 3 December 2014, 09:00-16:00 * Location: Moderated Poster area
Document Type
Article
Author
Wang, YS; Gong, X; Su, YG; Cui, J; Shu, XH; Perge, P; Kovacs, A; Liptai, C; Apor, A; Nagy, KV; Geller, L; Szeplaki, G; Merkely, B; Goebel, B; Hamadanchi, A; Schmidt-Winter, C; Otto, S; Jung, C; Figulla, HR; Poerner, TC; Rotzak, R; Aharonovich, A; Geva, Y; Rozenman, Y; Capotosto, L; D'angeli, I; Azzano, A; Placanica, A; Mukred, K; Rinaldi, E; Ashurov, R; Tanzilli, G; Mangieri, E; Vitarelli, A; Lesevic, H; Karl, M; Rosner, S; Ott, I; Sonne, C; Borges, I P; Peixoto, ECS; Peixoto, RTS; Peixoto, RTS; Marcolla, VF; Citro, R; Baldi, C; Provenza, G; Di Maio, M; Silverio, A; Prota, C; Di Muro, M R; Bossone, E; Giudice, P; Piscione, F; Muratori, M; Fusini, L; Gripari, P; Tamborini, G; Ghulam Ali, S; Salvi, L; Bartorelli, AL; Agrifoglio, M; Alamanni, F; Pepi, M; Fusini, L; Tamborini, G; Muratori, M; Cefalu', C; Bottari, VE; Gripari, P; Ghulam Ali, S; Andreini, D; Pontone, G; Pepi, M
Source
European Journal of Echocardiography; December 2014, Vol. 15 Issue: Supplement 2 pii20-ii20, 1p
Subject
Language
ISSN
15252167; 15322114
Abstract
Objective: To assess left ventricular (LV) twist by three-dimensional speckle tracking imaging (3D-STI) in a pacing induced heart failure canine model with left bundle-branch block (LBBB) undergoing cardiac resynchronization therapy (CRT). Methods: After induction of left bundle branch block by radiofrequency ablation, rapid right ventricular pacing (RVP) at 200 beats/min was utilized in 22 adult beagle dogs for 6 weeks to induce heart failure. Then 15 dogs received CRT for 4 weeks and others were treated as control. Apical full-volume acquisition of the LV was obtained in conscious animals at baseline, the end of 6-week RVP and the end of 4-week CRT. Peak LV systolic twist (Ptw) and torsion (Ptor) along with peak apical and basal rotation were automatically calculated by Tom-Tec 4D LV Analysis 3.0 software to identify the ideal parameter in predicting treatment response of CRT. Results: After 4 weeks of CRT, LVEF increased [(31.97 ± 1.47) vs. (37.47 ± 3.60)%, p=0.002] and LVESV decreased [(24.13 ± 3.72) vs. (21.87 ± 3.15)ml, p=0.007] significantly in dogs with heart failure. By shortening the delay of basal rotation [(23.73 ± 9.98) vs. (17.87 ± 5.94)ms, p=0.009], CRT improved peak LV systolic twist [(6.88 ± 0.99) vs. (8.03 ± 0.63)°, p=0.008] and torsion [(1.21 ± 0.36) vs. (1.98 ± 0.39)°/cm, p=0.010] instead of peak apical [(5.97 ± 0.57) vs. (6.13 ± 0.61)°, p=0.103] and basal rotation [(2.08 ± 0.45) vs. (2.13 ± 0.46)°, p=0.469]. CRT treatment response, defined as improvement of LVESV≥15%, was observed in 9 dogs. Significant difference was found in Ptw [(7.43 ± 0.61) vs. (6.06 ± 0.89)°, p=0.016] and Ptor [(1.43 ± 0.45) vs. (0.67 ± 0.36)°/cm, p=0.042] between responders and nonresponders. The cut-off values derived from receiver-operating characteristic curve analysis were 6.73° for Ptw and 1.00°/cm for Ptor with satisfying sensitivity as 89% and 85%, specificity as 83% and 84%, respectively. Conclusions: CRT improved LV systolic twist and reversed LV remodeling by reconciling basal with apical rotation. Peak twist and torsion evaluated by 3D-STI demonstrated potential prediction value for treatment response of CRT.