학술논문
Essential requirement of mammalian Pumiliofamily in embryonic development
Document Type
Article
Author
Source
Molecular Biology of the Cell; November 2018, Vol. 29 Issue: 24 p2922-2932, 11p
Subject
Language
ISSN
10591524; 19394586
Abstract
Loss of mouse Pum1 and Pum2 led to embryonic lethality by embryonic day 8.5. Gastrulation failure and reduced growth occurred in Pum1- and Pum2-deficient embryos. Gata6 expression increased in embryonic stem cells (ESCs) and embryos in the absence of Pum1 and Pum2. PUM1-mediated posttranscriptional regulation of Gata6 expression in ESCs is important for gastrulation.