학술논문
Transcriptional analysis of mouse wounds grafted with human mesenchymal stem cells and platelets
Document Type
Article
Source
STAR Protocols; September 2021, Vol. 2 Issue: 3
Subject
Language
ISSN
26661667
Abstract
Platelet preparations are commonly used in the clinic in combination with mesenchymal stem cells (MSCs) to improve their wound healing capacity and optimize their therapeutic efficacy following their delivery into diseased tissues. To investigate the mechanisms by which platelets enhance the repair properties of MSCs, we detail a protocol using a humanized mouse model for excisional wounds to study by reverse transcription real-time PCR whether human platelets alter the therapeutic efficacy of grafted human MSCs.