학술논문
MCR-1 and OXA-48 In VivoAcquisition in KPC-Producing Escherichia coliafter Colistin Treatment
Document Type
Article
Author
Source
Antimicrobial Agents and Chemotherapy; May 2017, Vol. 61 Issue: 8
Subject
Language
ISSN
00664804; 10986596
Abstract
ABSTRACTThe spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceaeraises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1in a carbapenem-resistant Escherichia colistrain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniaecarbapenemase-producing E. colistrain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1in carbapenemase-encoding bacteria in France.