학술논문
Quality of Life in Patients Treated with First-Line Antiretroviral Therapy Containing Nevirapine And/Or Efavirenz
Document Type
Article
Author
van Leth, Frank; Conway, Brian; Laplumé, Hector; Martin, Des; Fisher, Martin; Jelaska, Ante; Wit, Ferdinand W; Lange, Joep MA; Laplumé, H; Lasala, MB; Losso, MH; Bogdanowicz, E; Lattes, R; Krolewiecki, A; Zala, C; Orcese, C; Terlizzi, S; Duran, A; Ebensrteijn, J; Bloch, M; Russell, O; Russell, DB; Roth, NR; Eu, B; Austin, D; Gowers, A; Quan, D; Demonty, J; Peleman, R; Vandercam, B; Vogelaers, D; van der Gucht, B; van Wanzeele, F; Moutschen, MM; Badaro, R; Grinsztejn, B; Schechter, M; Uip, D; Netto, EN; Coelho, SS; Badaró, F; Pilotto, JH; Schubach, A; Barros, ML; Leite, OHM; Kiffer, CRV; Wunsch, CT; Nunes, D; Catalani, A; de Cassia Alves, Lira R; Dossin, TJ; D'Alló de Oliveira, MT; Martini, S; Conway, B; de Wet, JJ; Montaner, JSG; Murphy, C; Woodfall, B; Sestak, P; Phillips, P; Montessori, V; Harris, M; Tesiorowski, A; Willoughby, B; Voigt, R; Farley, J; Reynolds, R; Devlaming, S; Livrozet, JM; Rozenbaum, W; Sereni, D; Valantin, MA; Lascoux, C; Milpied, B; Brunet, C; Billaud, E; Huart, A; Reliquet, V; Charonnat, MF; Sicot, M; Esnault, JL; Slama, L; Staszewski, S; Bickel, M; Lazanas, MK; Stavrianeas, N; Mangafas, N; Zagoreos, I; Kourkounti, S; Paparizos, V; Botsi, Ch; Clarke, S; Brannigan, E; Boyle, N; Chiriani, A; Leoncini, F; Montella, F; Francesco, L; Ambu, S; Farese, A; Gargiulo, M; Di Sora, F; Lavria, F; Folgori, F; Beniowski, M; Boron Kaczmarska, A; Halota, W; Prokopowicz, D; Bander, DB; Leszuzyszyn-Pynka, MLP; Wnuk, AW; Bakowska, E; Pulik, P; Flisiak, R; Wiercinska-Drapalo, A; Mularska, E; Witor, A; Antunes, F; Sarmento, RSE; Doroana, M; Horta, AA; Vasconcelos, O; Andrews, SM; Huisamen, CB; Johnson, D; Martin, O; Bekker, L-G; Maartens, G; Wilson, D; Visagie, CJ; David, NJ; Rattley, M; Nettleship, E; Martin, DJ; Keyser, V; Moraites, TM; Moorhouse, MA; Pitt, JA; Orrell, CJ; Bester, C; Parboosing, R; Moodley, P; Gathiram, V; Woolf, D; Bernasconi, E; Magenta, L; Cardiello, P; Kroon, E; Ungsedhapand, C; Fisher, M; Wilkins, EGL; Stockwell, E; Day, J; Daintith, RS; Perry, N; Timaeus, C; Intosh-Roffet, J Mc; Powell, A; Youle, M; Tyrer, M; Madge, S; Drinkwater, A; Cuthbertson, Z; Carroll, A; Becker, S; Katner, H; Rimland, D; Saag, MS; Thompson, M; Witt, M; Aguilar, MM; LaVoy, A; Illeman, M; Guerrero, M; Gatell, J; Belsey, E; Hirschel, B; Potarca, A; Cronenberg, M; Kreekel, L; Meester, R; Khodabaks, J; Botma, H-J; Esrhir, N; Farida, I; Feenstra, M; Jansen, K; Klotz, A; Mulder, M; Ruiter, G; Bass, CB; Pluymers, E; de Vlegelaer, E; Leeneman (VCL), R; Carlier, H; van Steenberge, E; Hall, D
Source
Antiviral Therapy; July 2004, Vol. 9 Issue: 5 p721-728, 8p
Subject
Language
ISSN
13596535
Abstract
Objective To assess whether differences in safety profiles between nevirapine (NVP) and efavirenz (EFV), as observed in the 2NN study, translated into differences in ‘health related quality of life’ (HRQoL).Design A sub-study of the 2NN study, with antiretro-viral-naive patients randomly allocated to NVP (once or twice daily), EFV or NVP+EFV, in addition to stavudine and lamivudine.Methods Comparing differences in changes of HRQoL over 48 weeks as measured with the Medical Outcomes Study HIV Health Survey (MOS-HIV) questionnaire, using analysis of variance.Results The 2NN study enrolled 1216 patients. No validated questionnaires were available for 244 patients, and 55 patients had no HRQoL data at all, leaving 917 patients eligible for this sub-study. A total of 471 (51%) had HRQoL measurements both at baseline and week 48. The majority (69%) of patients without HRQoL measurements did, however, complete the study. The change in the physical health score (PHS) was 3.9 for NVP, 3.4 for EFV and 2.4 for NVP+EFV (P=0.712). For the mental health score (MHS) these values were 6.1, 7.0 and 3.9, respectively (P=0.098). A baseline plasma HIV-1 RNA concentration (pVL) =100 000 copies/ml and a decline in pVL (per log10) were independently associated with an increase of PHS. An increase of MHS was only associated with pVL decline. Patients experiencing an adverse event during follow-up had a comparable change in PHS but a significantly smaller change in MHS, compared with those without an adverse event.Conclusions First-line ART containing NVP and/or EFV leads to an improvement in HRQoL. The gain in HRQoL was similar for NVP and EFV, but slightly lower for the combination of these drugs.