학술논문
Ticagrelor versus clopidogrel in elective percutaneous coronary intervention (ALPHEUS): a randomised, open-label, phase 3b trial
Document Type
Article
Author
Silvain, Johanne; Lattuca, Benoit; Beygui, Farzin; Rangé, Grégoire; Motovska, Zuzana; Dillinger, Jean-Guillaume; Boueri, Ziad; Brunel, Philippe; Lhermusier, Thibault; Pouillot, Christophe; Larrieu-Ardilouze, Elisa; Boccara, Franck; Labeque, Jean-Noël; Guedeney, Paul; El Kasty, Mohamad; Laredo, Mikael; Dumaine, Raphaëlle; Ducrocq, Grégory; Collet, Jean-Philippe; Cayla, Guillaume; Blanchart, Katrien; Kala, Petr; Vicaut, Eric; Montalescot, Gilles; SILVAIN, Johanne; COLLET, Jean-Philippe; MONTALESCOT, Gilles; KERNEIS, Mathieu; BRAIK, Nassim; BARTHELEMY, Olivier; HELFT, Gérard; LEFEUVRE, Claude; CHOUSSAT, Rémi; HAUGUEL, Marie; ZEITOUNI, Michel; CUISSET, Thomas; BONNET, Jean-Louis; DEHARO, Pierre; LATTUCA, Benoit; CAYLA, Guillaume; CORNILLET, Luc; LEDERMANN, Bertrand; LONJON, Clément; SCHMUTZ, Laurent; RANGE, Grégoire; ALBERT, Franck; DEMICHELI, Thibault; ROUSSEL, Laurent; BENSAID, Reda; THUAIRE, Christophe; DILLINGER, Jean-Guillaume; HENRY, Patrick; MANZO-SILBERMAN, Stéphane; SIDERIS, Georgios; LOGEART, Damien; SPAGNOLI, Vincent; CACOUB, Léa; POUILLOT, Christophe; VI-FANE, Jean Richard; GLASENAPP, Jens; BOUGRINI, Karim; COMBARET, Nicolas; MOTREFF, Pascal; SOUTEYRAND, Géraud; AMONCHOT, Aimé; MOUYEN, Thomas; LHERMUSIER, Thibault; CARRIE, Didier; BOUISSET, Frédéric; CHOLLET, Thomas; CAMPELO-PARADA, Francisco; DELARCHE, Nicolas; SCHIELE, François; BESUTTI, Mathieu; HAUGUEL-MOREAU, Marie; EL MAHMOUD, Rami; CAUSSIN, Christophe; ZOHEIR, Mami; VEUGEOIS, Aurelie; DIBIE, Alain; VARENNE, Olivier; PICARD, Fabien; LAFONT, Alexandre; ADJEDJ, Julien; DEGRELL, Philippe; BEYGUI, Farzin; SABATIER, Rémi; ROULE, Vincent; BIGNON, Mathieux; BLANCHART, Katrien; ARDOUIN, Pierre; LEMAITRE, Adrien; BRIET, Clément; BOUERI, Ziad; GOUBE, Pascal; COSTE, Pierre; CETRAN, Laura; CLERC, Jérôme; LE BRETON, Hervé; BOULMIER, Dominique; AUFFRET, Vincent; LABEQUE, Jean-Noël; BONAS, Jean-Luc; GEORGES, Jean-Louis; LIVAREK, Bernard; BLICQ, Elodie; BARON, Nicolas; GIBAULT-GENTY, Géraldine; COTTIN, Yves; LHUILLIER, Isabelle; RICHARD, Carole; LORGIS, Luc; BUFFET, Philippe; SPAULDING, Christian; KARAM, Nicole; PUYMIRAT, Etienne; MENNUNI, Marco; POULIDAKIS, Emmanuel; BONNEVIE, Lionel; BOCCARA, Franck; CHAUVET, Marion; DUFOUR, Laurie; ANCEDY, Yann; EDERHY, Stéphane; ETIENNEY, Arnaud; BELLEMAIN-APPAIX, Anne; BITTON, Nathaniel; JACQ, Laurent; SAINT-ETIENNE, Christophe; LECLERCQ, Florence; ROUBILLE, François; RIOUFOL, Gilles; DERIMAY, François; GORALSKI, Marc; YAFI, Wael; FILIPPI, Emmanuelle; KERMARREC, Alain; LE RAY, Christophe; MERLET, Antoine; LOIRAT, Aurelie; BRUNEL, Philippe; BRUNET, Damien; RAVISY, Jack; MOCK, Laurent; MOLINS, Guillaume; CARRE, Max; BRESSOLLETTE, Erwan; CHRISTIAENS, Luc; LARRIEU-ARDILOUZE, Elisa; CADOR, Romain CADOR; VAN BELLE, Eric; LEMESLE, Gilles; DELHAYE, Cédric; VINCENT, Flavien; POROUCHANI, Sina; SPILLEMAEKER, Hugues; PETIT, Katy; RESSENCOURT, Olivier; CARRE, Max; HUMEAU, Vincent; JOURDA, François; ARNOULD, Marc-Antoine; CHASSAING, Stephen; ISAAZ, Karl; PAYOT, Laurent; MONTSEGU, Jacques; FAURIE, Benjamin; PANSIERI, Michel; METGE, Marc; MOUSSA, Karim; PANKERT, Mathieu; MOREL, Olivier; HESS, Sébastien; MAILLARD, Luc; MANIGOLD, Thibault; LETOCART, Vincent; PLESSIS, Julien; BERTHOME, Pauline; BONIN, Mickael; HUCHET, François; TEIGER, Emmanuel; GALLET, Romain; MOUILLET, Gauthier; BOUKANTAR, Madjid; EL MAHMOUD, Rami; NEJJARI, Mohammed; ATTIAS, David; CACOUB, Léa; STEINECKER, Mathieu; HUCHET, François; MOTOVSKA, Zuzana; KOZEL, Martin; STELMACH, Zdenko; HLINOMAZ, Ota; REZEK, Michal; NOVAK, Martin; SITAR, Jan; SEMENKA, Jiri; KALA, Petr; BOCEK, Otakar; ŠTIPAL, Roman; POLOCZEK, Martin; KANOVSKÝ, Jan; JERABEK, Petr; KARASEK, Jiří; HRUSKOVA, Sylvie; BRANNY, Marian; MROZEK, Jan; GREZL, Tomas; PLEVA, Leos; KUKLA, Pavel; PORZER, Martin
Source
The Lancet; November-December 2020, Vol. 396 Issue: 10264 p1737-1744, 8p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Percutaneous coronary intervention (PCI)-related myonecrosis is frequent and can affect the long-term prognosis of patients. To our knowledge, ticagrelor has not been evaluated in elective PCI and could reduce periprocedural ischaemic complications compared with clopidogrel, the currently recommended treatment. The aim of the ALPHEUS study was to examine if ticagrelor was superior to clopidogrel in reducing periprocedural myocardial necrosis in stable coronary patients undergoing high-risk elective PCI.