학술논문
The Management of Hepatitis B Virus/HIV-1 Co-Infected Patients Starting Their First Haart Regimen. Treating Two Infections for the Price of One Drug?
Document Type
Article
Author
Puoti, Massimo; Cozzi-Lepri, Alessandro; Ancarani, Fausto; Bruno, Raffaele; Ambu, Silvia; Ferraro, Teresa; Tundo, Paolo; Santantonio, Teresa; Toti, Mario; Bonasso, Marino; Monforte, Antonella d'Arminio; Ancarani, F; Antonucci, G; Bonasso, M; Bruno, R; Cozzi-Lepri, A; Monforte, A d'Arminio; Luca, A De; Galli, M; Gennero, L; Girardi, E; Lipani, F; Marino, N; Milazzo, L; Morsica, G; Narciso, P; Pizzaferri, P; Puoti, M; Santantonio, T; Verucchi, G; Montroni, M; Scalise, G; Zoli, A; Prete, MS Del; Tirelli, U; Di Gennaro, G; Pastore, G; Ladisa, N; Minafra, G; Suter, F; Arici, C; Chiodo, F; Colangeli, V; Fiorini, C; Coronado, O; Carosi, G; Cadeo, GP; Castelli, F; Minardi, C; Vangi, D; Rizzardini, G; Migliorino, G; Manconi, PE; Piano, P; Ferraro, T; Scerbo, A; Pizzigallo, E; D'Alessandro, M; Santoro, D; Pusterla, L; Carnevale, G; Galloni, D; Viganò, P; Mena, M; Ghinelli, F; Sighinolfi, L; Leoncini, F; Mazzotta, F; Pozzi, M; Lo Caputo, S; Angarano, G; Grisorio, B; Ferrara, S; Grima, P; Tundo, P; Pagano, G; Piersantelli, N; Alessandrini, A; Piscopo, R; Toti, M; Chigiotti, S; Soscia, F; Tacconi, L; Orani, A; Perini, P; Scasso, A; Vincenti, A; Chiodera, F; Castelli, P; Scalzini, A; Fibbia, G; Moroni, M; Lazzarin, A; Cargnel, A; Vigevani, GM; Caggese, L; d'Arminio Monforte, A; Repetto, D; Novati, R; Galli, A; Merli, S; Pastecchia, C; Moioli, MC; Esposito, R; Mussini, C; Abrescia, N; Chirianni, A; Izzo, C; Piazza, M; De Marco, M; Montesarchio, V; Manzillo, E; Graf, M; Colomba, A; Abbadessa, V; Prestileo, T; Mancuso, S; Ferrari, C; Pizzaferri, P; Filice, G; Minoli, L; Bruno, R; Novati, S; Balzelli, F; Loso, K; Petrelli, E; Cioppi, A; Alberici, F; Ruggieri, A; Menichetti, F; Martinelli, C; De Stefano, C; La Gala, A; Ballardini, G; Briganti, E; Magnani, G; Ursitti, MA; Arlotti, M; Ortolani, P; Ortona, L; Dianzani, F; Ippolito, G; Antinori, A; Antonucci, G; D'Elia, S; Narciso, P; Petrosillo, N; Vullo, V; De Luca, A; Del Forno, L; Zaccarelli, M; Acinapura, R; De Longis, P; Ciardi, M; D'Offizi, G; Trotta, MP; Noto, P; Lichtner, M; Capobianchi, MR; Girardi, E; Pezzotti, P; Rezza, G; Mura, MS; Mannazzu, M; Caramello, P; Sinicco, A; Soranzo, ML; Gennero, L; Sciandra, M; Bonasso, M; Grossi, PA; Basilico, C; Poggio, A; Bottari, G; Raise, E; Pasquinucci, S; De Lalla, F; Tositti, G; Resta, F; Chimienti, A; Cozzi-Lepri, A
Source
Antiviral Therapy; July 2004, Vol. 9 Issue: 5 p811-817, 7p
Subject
Language
ISSN
13596535
Abstract
We examined the impact of a lamivudine-containing highly active antiretroviral therapy (HAART) regimen on 164 hepatitis B virus/HIV co-infected individuals starting their first HAART. Lamivudine-treated patients (accounting for 73% of the study population) showed a significantly lower level of alanine aminotransferase over follow-up [–81.1 mU/ml mean difference; 95% confidence intervals (95% CI): –30.3; –131.7, P=0.003] and a significantly reduced risk of liver-related morbidity/mortality [Relative hazard (RH)=0.07; 95% CI: 0.01–0.38, P=0.002] than those starting a lamivudine sparing-regimen.