학술논문
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Document Type
Article
Author
Brouwer, Rachel M.; Klein, Marieke; Grasby, Katrina L.; Schnack, Hugo G.; Jahanshad, Neda; Teeuw, Jalmar; Thomopoulos, Sophia I.; Sprooten, Emma; Franz, Carol E.; Gogtay, Nitin; Kremen, William S.; Panizzon, Matthew S.; Olde Loohuis, Loes M.; Whelan, Christopher D.; Aghajani, Moji; Alloza, Clara; Alnæs, Dag; Artiges, Eric; Ayesa-Arriola, Rosa; Barker, Gareth J.; Bastin, Mark E.; Blok, Elisabet; Bøen, Erlend; Breukelaar, Isabella A.; Bright, Joanna K.; Buimer, Elizabeth E. L.; Bülow, Robin; Cannon, Dara M.; Ciufolini, Simone; Crossley, Nicolas A.; Damatac, Christienne G.; Dazzan, Paola; de Mol, Casper L.; de Zwarte, Sonja M. C.; Desrivières, Sylvane; Díaz-Caneja, Covadonga M.; Doan, Nhat Trung; Dohm, Katharina; Fröhner, Juliane H.; Goltermann, Janik; Grigis, Antoine; Grotegerd, Dominik; Han, Laura K. M.; Harris, Mathew A.; Hartman, Catharina A.; Heany, Sarah J.; Heindel, Walter; Heslenfeld, Dirk J.; Hohmann, Sarah; Ittermann, Bernd; Jansen, Philip R.; Janssen, Joost; Jia, Tianye; Jiang, Jiyang; Jockwitz, Christiane; Karali, Temmuz; Keeser, Daniel; Koevoets, Martijn G. J. C.; Lenroot, Rhoshel K.; Malchow, Berend; Mandl, René C. W.; Medel, Vicente; Meinert, Susanne; Morgan, Catherine A.; Mühleisen, Thomas W.; Nabulsi, Leila; Opel, Nils; de la Foz, Víctor Ortiz-García; Overs, Bronwyn J.; Paillère Martinot, Marie-Laure; Redlich, Ronny; Marques, Tiago Reis; Repple, Jonathan; Roberts, Gloria; Roshchupkin, Gennady V.; Setiaman, Nikita; Shumskaya, Elena; Stein, Frederike; Sudre, Gustavo; Takahashi, Shun; Thalamuthu, Anbupalam; Tordesillas-Gutiérrez, Diana; van der Lugt, Aad; van Haren, Neeltje E. M.; Wardlaw, Joanna M.; Wen, Wei; Westeneng, Henk-Jan; Wittfeld, Katharina; Zhu, Alyssa H.; Zugman, Andre; Armstrong, Nicola J.; Bonfiglio, Gaia; Bralten, Janita; Dalvie, Shareefa; Davies, Gail; Di Forti, Marta; Ding, Linda; Donohoe, Gary; Forstner, Andreas J.; Gonzalez-Peñas, Javier; Guimaraes, Joao P. O. F. T.; Homuth, Georg; Hottenga, Jouke-Jan; Knol, Maria J.; Kwok, John B. J.; Le Hellard, Stephanie; Mather, Karen A.; Milaneschi, Yuri; Morris, Derek W.; Nöthen, Markus M.; Papiol, Sergi; Rietschel, Marcella; Santoro, Marcos L.; Steen, Vidar M.; Stein, Jason L.; Streit, Fabian; Tankard, Rick M.; Teumer, Alexander; van ‘t Ent, Dennis; van der Meer, Dennis; van Eijk, Kristel R.; Vassos, Evangelos; Vázquez-Bourgon, Javier; Witt, Stephanie H.; Adams, Hieab H. H.; Agartz, Ingrid; Ames, David; Amunts, Katrin; Andreassen, Ole A.; Arango, Celso; Banaschewski, Tobias; Baune, Bernhard T.; Belangero, Sintia I.; Bokde, Arun L. W.; Boomsma, Dorret I.; Bressan, Rodrigo A.; Brodaty, Henry; Buitelaar, Jan K.; Cahn, Wiepke; Caspers, Svenja; Cichon, Sven; Crespo-Facorro, Benedicto; Cox, Simon R.; Dannlowski, Udo; Elvsåshagen, Torbjørn; Espeseth, Thomas; Falkai, Peter G.; Fisher, Simon E.; Flor, Herta; Fullerton, Janice M.; Garavan, Hugh; Gowland, Penny A.; Grabe, Hans J.; Hahn, Tim; Heinz, Andreas; Hillegers, Manon; Hoare, Jacqueline; Hoekstra, Pieter J.; Ikram, Mohammad A.; Jackowski, Andrea P.; Jansen, Andreas; Jönsson, Erik G.; Kahn, Rene S.; Kircher, Tilo; Korgaonkar, Mayuresh S.; Krug, Axel; Lemaitre, Herve; Malt, Ulrik F.; Martinot, Jean-Luc; McDonald, Colm; Mitchell, Philip B.; Muetzel, Ryan L.; Murray, Robin M.; Nees, Frauke; Nenadić, Igor; Oosterlaan, Jaap; Ophoff, Roel A.; Pan, Pedro M.; Penninx, Brenda W. J. H.; Poustka, Luise; Sachdev, Perminder S.; Salum, Giovanni A.; Schofield, Peter R.; Schumann, Gunter; Shaw, Philip; Sim, Kang; Smolka, Michael N.; Stein, Dan J.; Trollor, Julian N.; van den Berg, Leonard H.; Veldink, Jan H.; Walter, Henrik; Westlye, Lars T.; Whelan, Robert; White, Tonya; Wright, Margaret J.; Medland, Sarah E.; Franke, Barbara; Thompson, Paul M.; Hulshoff Pol, Hilleke E.
Source
Nature Neuroscience; April 2022, Vol. 25 Issue: 4 p421-432, 12p
Subject
Language
ISSN
10976256; 15461726
Abstract
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1and APOEare associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.