학술논문
Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
Document Type
Article
Author
Dawed, Adem Y; Mari, Andrea; Brown, Andrew; McDonald, Timothy J; Li, Lin; Wang, Shuaicheng; Hong, Mun-Gwan; Sharma, Sapna; Robertson, Neil R; Mahajan, Anubha; Wang, Xuan; Walker, Mark; Gough, Stephen; Hart, Leen M ‘t; Zhou, Kaixin; Forgie, Ian; Ruetten, Hartmut; Pavo, Imre; Bhatnagar, Pallav; Jones, Angus G; Pearson, Ewan R; 't Hart, L.M.; Abdalla, M.; Adam, J.; Adamski, J.; Adragni, K.; Allin, K.H.; Arumugam, M.; Atabaki Pasdar, N.; Baltauss, T.; Banasik, K.B.; Baum, P.; Bell, J.D.; Bergstrom, M.; Beulens, J.W.; Bianzano, S.; Bizzotto, R.; Bonneford, A.; Brorsson, C.A.B.; Brown, A.A.; Brunak, S.B.; Cabrelli, L.; Caiazzo, R.; Canouil, M.; Dale, M.; Davtian, D.; Dawed, A.Y.; De Masi, F.M.; de Preville, N.; Dekkers, K.F.; Dermitzakis, E.T.; Deshmukh, H.A.; Dings, C.; Donnelly, L.; Dutta, A.; Ehrhardt, B.; Elders, P.J.M.; Engel Thomas, C.E.T.; Engelbrechtsen, L.; Eriksen, R.G.; Eriksen, R.E.; Fan, Y.; Fernandez, J.; Ferrer, J.; Fitipaldi, H.; Forgie, I.M.; Forman, A.; Franks, P.W.; Frau, F.; Fritsche, A.; Froguel, P.; Frost, G.; Gassenhuber, J.; Giordano, G.N.; Giorgino, T.; Gough, S.; Graefe-Mody, U.; Grallert, H.; Grempler, R.; Groeneveld, L.; Groop, L.; Gudmundsdóttir, V.G.; Gupta, R.G.; Haid, M.; Hansen, T.; Hansen, T.H.; Hattersley, A.T.; Haussler, R.S.; Heggie, A.J.; Hennige, A.M.; Hill, A.V.; Holl, R.W.; Hong, M.-G.; Hudson, M.; Jablonka, B.; Jennison, C.; Jiao, J.; Johansen, J.J.; Jones, A.G.; Jonsson, A.; Karaderi, T.K.; Kaye, J.; Klintenberg, M.; Koivula, R.W.; Kokkola, T.; Koopman, A.D.M.; Kurbasic, A; Kuulasmaa, T.; Laakso, M.; Lehr, T.; Loftus, H.; Lundbye Allesøe, R.L.A; Mahajan, A.; Mari, A.; Mazzoni, G.M.; McCarthy, M.I.; McDonald, T.J.; McEvoy, D.; McRobert, N.; McVittie, I.; Mourby, M.; Musholt, P.; Mutie, P; Nice, R.; Nicolay, C.; Nielsen, A.M.N.; Nilsson, B.N.; Palmer, C.N.; Pattou, F.; Pavo, I.; Pearson, E.R.; Pedersen, O.; Pedersen, H.K.P.; Perry, M.H.; Pomares-Millan, H.; Ramisch, A.; Rasmussen, S.R.; Raverdi, V.; Ridderstrale, M.; Robertson, N.; Roderick, R.C.; Rodriquez, M.; Ruetten, H.; Rutters, F.; Sackett, W.; Scherer, N.; Schwenk, J.M.; Shah, N.; Sharma, S.; Sihinevich, I.; Sondertoft, N.B.; Staerfeldt, H.; Steckel-Hamann, B.; Teare, H.; Thomas, M.K.; Thomas, E.L.; Thomsen, H.S.; Thorand, B.; Thorne, C.E.; Tillner, J.; Troen Lundgaard, A.T.L.; Troll, M.; Tsirigos, K.D.T.; Tura, A.; Uhlen, M.; van Leeuwen, N.; van Oort, S.; Verkindt, H.; Vestergaard, H.; Viñuela, A.; Vogt, J.K; Wad Sackett, P.W.S; Wake, D.; Walker, M.; Wesolowska-Andersen, A.; Whitcher, B.; White, M.W.; Wu, H.
Source
The Lancet Diabetes & Endocrinology; January 2023, Vol. 11 Issue: 1 p33-41, 9p
Subject
Language
ISSN
22138587; 22138595
Abstract
In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacogenomic studies of this inter-individual variation can provide both biological insight into drug action and provide biomarkers to inform clinical decision making. We therefore aimed to identify genetic variants associated with glycaemic response to GLP-1 receptor agonist treatment.