학술논문
Efficacy of DHMEQ, a NF-B Inhibitor, in Islet Transplantation
Document Type
Article
Author
Source
Transplantation; September 2013, Vol. 96 Issue: 5 p445-453, 9p
Subject
Language
ISSN
00411337; 15346080
Abstract
Pancreatic islet transplantation (PITx) is an attractive treatment option for restoring appropriate glucose homeostasis in type 1 diabetes patients. Although islet grafts can successfully engraft after PITx, large numbers of islet grafts are required mainly because immune reactions, including inflammation, destroy islet grafts. In these processes, nuclear factor (NF)-B plays a central role. We hypothesized that the inhibition of NF-B activation would ameliorate inflammatory responses after PITx and aid successful engraftment.