학술논문
Streptocinnamides A and B, Depsipeptides from Streptomycessp. KMM 9044
Document Type
Article
Author
Makarieva, Tatyana N.; Romanenko, Lyudmila A.; Mineev, Konstantin S.; Shubina, Larisa K.; Guglya, Elena B.; Kalinovskaya, Natalia I.; Ivanchina, Natalia V.; Guzii, Alla G.; Belozerova, Olga A.; Kovalchuk, Sergey I.; Popov, Roman S.; Denisenko, Vladimir A.; Mikhailov, Valery V.; Babenko, Vladislav V.; Ilina, Elena N.; Malakhova, Maja V.; Terekhov, Stanislav S.; Kudzhaev, Arsen M.; Dmitrenok, Pavel S.; Yampolsky, Ilia V.; Stonik, Valentin A.
Source
Organic Letters; July 2022, Vol. 24 Issue: 27 p4892-4895, 4p
Subject
Language
ISSN
15237060; 15237052
Abstract
The bacterium Streptomycessp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A (1) and B (2), representatives of a new structural group of antibiotics. The structures of 1and 2were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits Micrococcussp. KMM 1467, Arthrobactersp. ATCC 21022, and Mycobacterium smegmatisMC2 155.