학술논문
Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial
Document Type
Article
Author
Bauer, Axel; Schreinlechner, Michael; Sappler, Nikolay; Dolejsi, Theresa; Tilg, Herbert; Aulinger, Benedikt A; Weiss, Günter; Bellmann-Weiler, Rosa; Adolf, Christian; Wolf, Dominik; Pirklbauer, Markus; Graziadei, Ivo; Gänzer, Hannes; von Bary, Christian; May, Andreas E; Wöll, Ewald; von Scheidt, Wolfgang; Rassaf, Tienush; Duerschmied, Daniel; Brenner, Christoph; Kääb, Stefan; Metzler, Bernhard; Joannidis, Michael; Kain, Hans-Ulrich; Kaiser, Norbert; Schwinger, Robert; Witzenbichler, Bernhard; Alber, Hannes; Straube, Florian; Hartmann, Niels; Achenbach, Stephan; von Bergwelt-Baildon, Michael; von Stülpnagel, Lukas; Schoenherr, Sebastian; Forer, Lukas; Embacher-Aichhorn, Sabine; Mansmann, Ulrich; Rizas, Konstantinos D; Massberg, Steffen; Bantkowiak, Marcin; Baur, Gabriele; Baylacher, Monika; Beaucamp, Marcel; Berger, Manuel; Besch, Lisa; Brunner, Stefan; Budweiser, Stephan; Bugger, Heiko; Coletti, Raffaele; Dorwarth, Uwe; Egresits, Jozsef; Eiffener, Elodie; Faul, Christian; Finkenstedt, Armin; Gatos, Konstantinos; Gauchel, Nadine; Gindele, Frank; Grander, Wilhelm; Gunschl, Markus; Hartig, Frank; Hecht, Moritz; Heer, Tobias; Heger, Lukas; Hentrich, Marcus; Horvath, Lena; Keta, Dritan; Kiechl, Stefan; Kirchmaier, Rudolf; Klein, Andreas; Klemm, Mathias; Kolesnik, Ewald; König, Andreas; Kossmann, Hans Christian; Kropacek, Jana; Lanser, Lukas; Lother, Achim; Löw, Anja; Mahabadi, Amir-Abbas; Malleier, Stefan; Mayer, Gert; Müller, Christoph; Müller-Wieland, Dirk; Nagel, Bernhard; Neuwirt, Hannes; Olivier, Christoph; Raunegger, Thomas; Reindl, Martin; Reinstadler, Sebastian; Riesinger, Lisa; Schäffner, Michael; Schier, Johannes; Schock, Julia; Schönherr, Peter; Schulz, Martina; Schütz, Thomas; Schwarz, Johannes; Siebermair, Johannes; Siry, Marcus; Spaur, Anna; Sturm, Wolfgang; Tessadri, Kristin; Theurl, Fabian; Theurl, Markus; Thommes, Liz; Tiller, Christina; Toifl, Michael; Totzeck, Matthias; von zur Mühlen, Hedda; Vonderlin, Nadine; Wakili, Reza; Wendtner, Clemens; Wenner, Felix; Wimmert-Roidl, Daniela; Zabernigg, August
Source
The Lancet Respiratory Medicine; August 2021, Vol. 9 Issue: 8 p863-872, 10p
Subject
Language
ISSN
22132600; 22132619
Abstract
SARS-CoV-2 entry in human cells depends on angiotensin-converting enzyme 2, which can be upregulated by inhibitors of the renin–angiotensin system (RAS). We aimed to test our hypothesis that discontinuation of chronic treatment with ACE-inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) mitigates the course o\f recent-onset COVID-19.