학술논문
Transbronchial cryobiopsy followed by as-needed surgical lung biopsy versus immediate surgical lung biopsy for diagnosing interstitial lung disease (the COLD study): a randomised controlled trial
Document Type
Article
Author
Kalverda, Kirsten A; Ninaber, Maarten K; Wijmans, Lizzy; von der Thüsen, Jan; Jonkers, René E; Daniels, Johannes M; Miedema, Jelle R; Dickhoff, Chris; Hölters, Jürgen; Heineman, David; Kant, Merijn; Radonic, Teodora; Shahin, Ghada; Cohen, Danielle; Boerrigter, Bart; Nijman, Suzan; Nossent, Esther; Braun, Jerry; Mathot, Bas; Poletti, Venerino; Hetzel, Jürgen; Dijkgraaf, Marcel; Korevaar, Daniel A; Bonta, Peter I; Annema, Jouke T
Source
The Lancet Respiratory Medicine; 20240101, Issue: Preprints
Subject
Language
ISSN
22132600; 22132619
Abstract
An adequate diagnosis for interstitial lung disease (ILD) is important for clinical decision making and prognosis. In most patients with ILD, an accurate diagnosis can be made by clinical and radiological data assessment, but in a considerable proportion of patients, a lung biopsy is required. Surgical lung biopsy (SLB) is the most common method to obtain tissue, but it is associated with high morbidity and even mortality. More recently, transbronchial cryobiopsy has been introduced, with fewer adverse events but a lower diagnostic yield than SLB. The aim of this study is to compare two diagnostic strategies: a step-up strategy (transbronchial cryobiopsy, followed by SLB if the cryobiopsy is insufficiently informative) versus immediate SLB.