학술논문
Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial
Document Type
Article
Author
Paz-Ares, Luis; Dvorkin, Mikhail; Chen, Yuanbin; Reinmuth, Niels; Hotta, Katsuyuki; Trukhin, Dmytro; Statsenko, Galina; Hochmair, Maximilian J; Özgüroğlu, Mustafa; Ji, Jun Ho; Voitko, Oleksandr; Poltoratskiy, Artem; Ponce, Santiago; Verderame, Francesco; Havel, Libor; Bondarenko, Igor; Kazarnowicz, Andrzej; Losonczy, György; Conev, Nikolay V; Armstrong, Jon; Byrne, Natalie; Shire, Norah; Jiang, Haiyi; Goldman, Jonathan W; Batagelj, Emilio; Casarini, Ignacio; Pastor, Anea Viviana; Sena, Susana Noemi; Zarba, Juan Jose; Burghuber, Otto; Hartl, Sylvia; Hochmair, Maximilian J; Lamprecht, Bernd; Studnicka, Michael; Alberto Schlittler, Luis; Augusto Martinelli de Oliveira, Fabricio; Calabrich, Aknar; Colagiovanni Girotto, Gustavo; Dos Reis, Peo; Fausto Nino Gorini, Carlos; Rafael Martins De Marchi, Peo; Serodio da Rocha Baldotto, Clarissa; Sette, Claudia; Zukin, Mauro; Conev, Nikolay V; Dudov, Assen; Ilieva, Rumyana; Koynov, Krassimir; Krasteva, Rositsa; Tonev, Ivan; Valev, Spartak; Venkova, Violetka; Bi, Minghong; Chen, Chengshui; Chen, Yuan; Chen, Zhendong; Fang, Jian; Feng, Jifeng; Han, Zhigang; Hu, Jie; Hu, Yi; Li, Wei; Liang, Zongan; Lin, Zhong; Ma, Rui; Ma, Shenglin; Nan, Kejun; Shu, Yongqian; Wang, Kai; Wang, Mengzhao; Wu, Gang; Yang, Nong; Yang, Zhixiong; Zhang, Helong; Zhang, Wei; Zhao, Jun; Zhao, Yanqiu; Zhou, Caicun; Zhou, Jianying; Zhou, Xiangdong; Havel, Libor; Kolek, Vitezslav; Koubkova, Leona; Roubec, Jaromir; Skrickova, Jana; Zemanova, Milada; Chouaid, Christos; Hilgers, Werner; Lena, Hervé; Moro-Sibilot, Denis; Robinet, Gilles; Souquet, Pierre-Jean; Alt, Jürgen; Bischoff, Helge; Grohe, Christian; Laack, Eckart; Lang, Susanne; Panse, Jens; Reinmuth, Niels; Schulz, Christian; Bogos, Krisztina; Csánky, Eszter; Fülöp, Anea; Horváth, Zsolt; Kósa, Judit; Laczó, Ibolya; Losonczy, György; Pajkos, Gábor; Pápai, Zsuzsanna; Pápai Székely, Zsolt; Sárosi, Veronika; Somfay, Attila; Somogyiné Ezer, Éva; Telekes, Anás; Bar, Jair; Gottfried, Maya; Heching, Norman Isaac; Zer Kuch, Alona; Bartolucci, Roberta; Bettini, Anna Cecilia; Delmonte, Angelo; Garassino, Marina Chiara; Minelli, Mauro; Roila, Fausto; Verderame, Francesco; Atagi, Shinji; Azuma, Koichi; Goto, Hisatsugu; Goto, Koichi; Hara, Yu; Hayashi, Hidetoshi; Hida, Toyoaki; Hotta, Katsuyuki; Kanazawa, Kenya; Kanda, Shintaro; Kim, Young Hak; Kuyama, Shoichi; Maeda, Tadashi; Morise, Masahiro; Nakahara, Yasuharu; Nishio, Makoto; Nogami, Naoyuki; Okamoto, Isamu; Saito, Haruhiro; Shinoda, Masahiro; Umemura, Shigeki; Yoshida, Tatsuya; Claessens, Niels; Cornelissen, Robin; Heniks, Lizza; Hiltermann, Jeroen; Smit, Egbert; Staal van den Brekel, Agnes; Kazarnowicz, Andrzej; Kowalski, Dariusz; Mańdziuk, Slawomir; Mróz, Robert; Wojtukiewicz, Marek; Ciuleanu, Tudor; Ganea, Doina; Ungureanu, Anei; Dvorkin, Mikhail; Luft, Alexander; Moiseenko, Vladimir; Poltoratskiy, Artem; Sakaeva, Dina; Smolin, Alexey; Statsenko, Galina; Vasilyev, Alexander; Vladimirova, Lyubov; Anasina, Igor; Chovanec, Jozef; Demo, Pavol; Godal, Robert; Kasan, Peter; Stresko, Marian; Urda, Michal; Cho, Eun Kyung; Ji, Jun Ho; Kim, Joo-Hang; Kim, Sang-We; Lee, Gyeong-Won; Lee, Jong-Seok; Lee, Ki Hyeong; Lee, Kyung Hee; Lee, Yun Gyoo; Amelia Insa Molla, Maria; Domine Gomez, Manuel; Ignacio Delgado Mingorance, Juan; Isla Casado, Dolores; Lopez Brea, Marta; Majem Tarruella, Margarita; Morán Bueno, Teresa; Navarro Mendivil, Alejano; Paz-Ares Rodríguez, Luis; Ponce Aix, Santiago; Rosario Garcia Campelo, Maria; Chang, Gee-Chen; Chen, Yen-Hsun; Chiu, Chao-Hua; Hsia, Te-Chun; Lee, Kang-Yun; Li, Chien-Te; Wang, Chin-Chou; Wei, Yu-Feng; Wu, Shang-Yin; Alacacıoğlu, Ahmet; Çiçin, Irfan; Demirkazik, Ahmet; Erman, Mustafa; Göksel, Tuncay; Özgüroğlu, Mustafa; Adamchuk, Hryhoriy; Bondarenko, Igor; Kolesnik, Oleksii; Kryzhanivska, Anna; Ostapenko, Yuriv; Shevnia, Serhii; Shparyk, Yaroslav; Trukhin, Dmytro; Ursol, Grygorii; Voitko, Nataliia; Voitko, Oleksandr; Vynnychenko, Ihor; Babu, Sunil; Chen, Yuanbin; Chiang, Anne; Chua, Winston; Dakhil, Shaker; Dowlati, Afshin; Goldman, Jonathan W; Haque, Basir; Jamil, Rodney; Knoble, Jeanna; Lakhanpal, Shailena; Mi, Kailhong; Nikolinakos, Petros; Powell, Steven; Ross, Helen; Schaefer, Eric; Schneider, Jeffrey; Spahr, Joseph; Spigel, David; Stilwill, Joseph; Sumey, Christopher; Williamson, Michael
Source
The Lancet; November 2019, Vol. 394 Issue: 10212 p1929-1939, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation, and prognosis remains poor. Recently, immunotherapy has demonstrated clinical activity in extensive-stage SCLC (ES-SCLC). The CASPIAN trial assessed durvalumab, with or without tremelimumab, in combination with etoposide plus either cisplatin or carboplatin (platinum–etoposide) in treatment-naive patients with ES-SCLC.