학술논문
Midkine, a Retinoic Acid-Inducible Heparin-Binding Cytokine, Is a Novel Regulator of Intracellular Calcium in Human Neutrophils
Document Type
Article
Author
Source
Biochemical and Biophysical Research Communications; December 1997, Vol. 241 Issue: 3 p756-761, 6p
Subject
Language
ISSN
0006291X; 10902104
Abstract
Midkine (MK), which induces chemotaxis of human neutrophils, was found to trigger mobilization of intracellular calcium of these cells. The maximum response was observed 150 sec after exposure to MK, suggesting a complex mechanism in the process. The calcium mobilization was inhibited by herbimycin A,Bordetella pertussistoxin and wortmannin, suggesting that a tyrosine kinase, a G protein-linked receptor and phosphatidyl inositol 3 kinase are involved in the process.