학술논문
Galtonosides A–E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis
Document Type
Article
Author
Source
Journal of Natural Products; April 2020, Vol. 83 Issue: 4 p1043-1050, 8p
Subject
Language
ISSN
01633864; 15206025
Abstract
An extract of Galtonia regalisfrom the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC50value less than 1.25 μg/mL. The two known cholestane glycosides 1and 2and the five new cholestane glycosides galtonosides A–E (3–7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR and mass spectra. Among these compounds, galtonoside B (4) displayed the most potent antiplasmodial activity, with an IC50value of 0.214 μM against the drug-resistant Dd2 strain of Plasmodium falciparum.