학술논문
Loss of Dnmt3aincreases self-renewal and resistance to pegIFN-α in JAK2-V617F–positive myeloproliferative neoplasms
Document Type
Article
Author
Source
Blood; June 2024, Vol. 143 Issue: 24 p2490-2503, 14p
Subject
Language
ISSN
00064971; 15280020
Abstract
•Loss of Dnmt3aincreases self-renewal of JAK2-V617F HSCs and mitigates their attrition upon chronic pegIFN-α treatment.•A combination of pegIFN-α and 5-azacytidine can strongly decrease the JAK2-mutant allele burden in MPN driven by JAK2-V617F alone.