학술논문
Biology and pharmacology of recombinant human interleukin-1β-induced rat ear inflammation
Document Type
Article
Source
Inflammation Research; August 1987, Vol. 21 Issue: 3-4 p325-327, 3p
Subject
Language
ISSN
10233830; 1420908X
Abstract
A single, 10 ng intradermal injection of human recombinant interleukin-1β (rIL-1β) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1β injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1β induced inflammation.