학술논문
Comprehensive proteogenomic characterization of rare kidney tumors
Document Type
Article
Author
Li, Ginny Xiaohe; Chen, Lijun; Hsiao, Yi; Mannan, Rahul; Zhang, Yuping; Luo, Jie; Petralia, Francesca; Cho, Hanbyul; Hosseini, Noshad; Leprevost, Felipe da Veiga; Calinawan, Anna; Li, Yize; Anand, Shankara; Dagar, Aniket; Geffen, Yifat; Kumar-Sinha, Chandan; Chugh, Seema; Le, Anne; Ponce, Sean; Guo, Shenghao; Zhang, Cissy; Schnaubelt, Michael; Al Deen, Nataly Naser; Chen, Feng; Caravan, Wagma; Houston, Andrew; Hopkins, Alex; Newton, Chelsea J.; Wang, Xiaoming; Polasky, Daniel A.; Haynes, Sarah; Yu, Fengchao; Jing, Xiaojun; Chen, Siqi; Robles, Ana I.; Mesri, Mehdi; Thiagarajan, Mathangi; An, Eunkyung; Getz, Gad A.; Linehan, W. Marston; Hostetter, Galen; Jewell, Scott D.; Chan, Daniel W.; Wang, Pei; Omenn, Gilbert S.; Mehra, Rohit; Ricketts, Christopher J.; Ding, Li; Chinnaiyan, Arul M.; Cieslik, Marcin P.; Dhanasekaran, Saravana M.; Zhang, Hui; Nesvizhskii, Alexey I.; Lazar, Alexander J.; Paulovich, Amanda G.; Antczak, Andrzej; Green, Anthony; Ma’ayan, Avi; Pruetz, Barb; Zhang, Bing; Reva, Boris; Druker, Brian J.; Goldthwaite, Charles A.; Birger, Chet; Mani, D.R.; Chesla, David; Fenyö, David; Schadt, Eric E.; Wilson, George; Kołodziejczak, Iga; John, Ivy; Hafron, Jason; Vo, Josh; Zaalishvili, Kakhaber; Ketchum, Karen A.; Rodland, Karin D.; Nyce, Kristen; Wiznerowicz, Maciej; Domagalski, Marcin J.; Anurag, Meenakshi; Borucki, Melissa; Gillette, Michael A.; Birrer, Michael J.; Edwards, Nathan J.; Vatanian, Negin; VanderKolk, Pamela; McGarvey, Peter B.; Dhir, Rajiv; Thangudu, Ratna R.; Crispen, Reese; Smith, Richard D.; Payne, Samuel H.; Cottingham, Sandra; Cai, Shuang; Carr, Steven A.; Liu, Tao; Le, Toan; Ma, Weiping; Zhang, Xu; Lu, Yin; Shutack, Yvonne; Zhang, Zhen
Source
Cell Reports Medicine; May 2024, Vol. 5 Issue: 5
Subject
Language
ISSN
26663791
Abstract
Non-clear cell renal cell carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis of aggressive disease, and therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses of 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, and metabolic aberrations in RCC subtypes. RCCs with high genome instability display overexpression of IGF2BP3 and PYCR1. Integration of single-cell and bulk transcriptome data predicts diverse cell-of-origin and clarifies RCC subtype-specific proteogenomic signatures. Expression of biomarkers MAPRE3, ADGRF5, and GPNMB differentiates renal oncocytoma from chromophobe RCC, and PIGR and SOSTDC1 distinguish papillary RCC from MTSCC. This study expands our knowledge of proteogenomic signatures, biomarkers, and potential therapeutic targets in non-ccRCC.